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Prospective study of sentinel node biopsy for high-risk cutaneous squamous cell carcinoma of the head and neck.

Journal Article


Abstract


  • Background

    Nodal metastasis from cutaneous squamous cell carcinoma (SCC) is poorly predicted clinically and is associated with a high mortality rate.

    Methods

    From 2010 to 2013, patients with high-risk cutaneous SCC were assessed with sentinel node biopsy (SNB) either at the time of primary cutaneous tumor resection or at secondary wide local excision.

    Results

    Of 57 patients, 8 (14%) had nodal metastasis. Significant predictors of metastasis are the number of high-risk factors (p = .008), perineural invasion (PNI; p = .05), and lymphovascular invasion (LVI; p = .05). During a mean of 19.4 months, 9 patients developed recurrence and 6 died of cutaneous SCC, indicating that over 1300 patients would be required for a randomized controlled trial with 80% power to detect a significant difference in disease-free survival.

    Conclusion

    Lymph node metastasis occurs in 14% of patients with high-risk cutaneous SCC. Larger studies will be required to identify which "high-risk" factors should be considered as an indication for surgical assessment of the nodal basin. © 2015 Wiley Periodicals, Inc. Head Neck 38: E884-E889, 2016.

Publication Date


  • 2015

Citation


  • Gore, S. M., Shaw, D., Martin, R. C. W., Kelder, W., Roth, K., Uren, R., . . . Clark, J. R. (2016). Prospective study of sentinel node biopsy for high-risk cutaneous squamous cell carcinoma of the head and neck.. Head & neck, 38 Suppl 1, E884-E889. doi:10.1002/hed.24120

Web Of Science Accession Number


Start Page


  • E884

End Page


  • E889

Volume


  • 38 Suppl 1

Abstract


  • Background

    Nodal metastasis from cutaneous squamous cell carcinoma (SCC) is poorly predicted clinically and is associated with a high mortality rate.

    Methods

    From 2010 to 2013, patients with high-risk cutaneous SCC were assessed with sentinel node biopsy (SNB) either at the time of primary cutaneous tumor resection or at secondary wide local excision.

    Results

    Of 57 patients, 8 (14%) had nodal metastasis. Significant predictors of metastasis are the number of high-risk factors (p = .008), perineural invasion (PNI; p = .05), and lymphovascular invasion (LVI; p = .05). During a mean of 19.4 months, 9 patients developed recurrence and 6 died of cutaneous SCC, indicating that over 1300 patients would be required for a randomized controlled trial with 80% power to detect a significant difference in disease-free survival.

    Conclusion

    Lymph node metastasis occurs in 14% of patients with high-risk cutaneous SCC. Larger studies will be required to identify which "high-risk" factors should be considered as an indication for surgical assessment of the nodal basin. © 2015 Wiley Periodicals, Inc. Head Neck 38: E884-E889, 2016.

Publication Date


  • 2015

Citation


  • Gore, S. M., Shaw, D., Martin, R. C. W., Kelder, W., Roth, K., Uren, R., . . . Clark, J. R. (2016). Prospective study of sentinel node biopsy for high-risk cutaneous squamous cell carcinoma of the head and neck.. Head & neck, 38 Suppl 1, E884-E889. doi:10.1002/hed.24120

Web Of Science Accession Number


Start Page


  • E884

End Page


  • E889

Volume


  • 38 Suppl 1