Skip to main content
placeholder image

Improved survival with elective neck dissection in thick early-stage oral squamous cell carcinoma.

Journal Article


Abstract


  • Background

    Management of the node-negative neck in T1 to T2 oral squamous cell carcinoma (SCC) remains controversial. The purpose of this study was to determine if elective neck dissection improves outcomes in thick primary tumors since this reflects current practice in most institutions and has not been specifically addressed in the literature.

    Methods

    Retrospective analysis comparing elective neck dissection versus observation in 153 patients with T1 to T2 N0 oral SCC ≥4 mm thick.

    Results

    On multivariable analysis, elective neck dissection was a significant predictor of improved regional control (hazard ratio [HR], 0.1; p < .001), disease-specific (HR, 0.1; p < .001), and overall survival (HR, 0.3; p = .001). Regional failure accounted for 22% of disease-related deaths in the elective neck dissection group compared to 92% in the observation arm.

    Conclusion

    Elective neck dissection is associated with a clinically significant survival advantage in thick T1 to T2 oral SCC by reducing the risk of regional failure, and we support its routine application in these patients.

Publication Date


  • 2011

Citation


  • Ebrahimi, A., Ashford, B. G., & Clark, J. R. (2012). Improved survival with elective neck dissection in thick early-stage oral squamous cell carcinoma.. Head & neck, 34(5), 709-716. doi:10.1002/hed.21809

Web Of Science Accession Number


Start Page


  • 709

End Page


  • 716

Volume


  • 34

Issue


  • 5

Abstract


  • Background

    Management of the node-negative neck in T1 to T2 oral squamous cell carcinoma (SCC) remains controversial. The purpose of this study was to determine if elective neck dissection improves outcomes in thick primary tumors since this reflects current practice in most institutions and has not been specifically addressed in the literature.

    Methods

    Retrospective analysis comparing elective neck dissection versus observation in 153 patients with T1 to T2 N0 oral SCC ≥4 mm thick.

    Results

    On multivariable analysis, elective neck dissection was a significant predictor of improved regional control (hazard ratio [HR], 0.1; p < .001), disease-specific (HR, 0.1; p < .001), and overall survival (HR, 0.3; p = .001). Regional failure accounted for 22% of disease-related deaths in the elective neck dissection group compared to 92% in the observation arm.

    Conclusion

    Elective neck dissection is associated with a clinically significant survival advantage in thick T1 to T2 oral SCC by reducing the risk of regional failure, and we support its routine application in these patients.

Publication Date


  • 2011

Citation


  • Ebrahimi, A., Ashford, B. G., & Clark, J. R. (2012). Improved survival with elective neck dissection in thick early-stage oral squamous cell carcinoma.. Head & neck, 34(5), 709-716. doi:10.1002/hed.21809

Web Of Science Accession Number


Start Page


  • 709

End Page


  • 716

Volume


  • 34

Issue


  • 5