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Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib���pair linkage analysis

Journal Article


Abstract


  • The influence of genetic factors in schizophrenia has been convincingly demonstrated by family, twin and adoption studies1���3, but the mode of transmission remains uncertain. The reported pattern of recurrence risks suggests a set of interacting loci4. Based on prior evidence for linkage on chromosome 6p (K. Kendler, pers. comm.), we have scanned the short arm of chromosome 6 in 54 families for loci predisposing to schizophrenia, using 25 microsatellite markers spanning 60 centiMorgans (cM). Allele sharing identity by descent was examined in affected sib-pairs from these families, followed by multipoint sib-pair linkage analysis. Positive lod scores were obtained over a wide region (D6S470 to D6S271), with a maximum lod score of 2.2 occuring near D6S274, located in 6p22. However, we obtained a lod score of ���2 at D6S296, the locus found by others to provide the greatest linkage evidence5. At D6S274, we report a positive lod score as do Straub et al.5 (individually non-significant). A combined total lod of 3.6���4.0 suggests the possibility of a susceptibility locus in this region. However, methodological differences between our studies makes a firm conclusion difficult. �� 1995 Nature Publishing Group.

Publication Date


  • 1995

Citation


  • Schwab, S. G., Albus, M., Hallmayer, J., H��nig, S., Borrmann, M., Lichtermann, D., . . . Wildenauer, D. B. (1995). Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib���pair linkage analysis. Nature Genetics, 11(3), 325-327. doi:10.1038/ng1195-325

Scopus Eid


  • 2-s2.0-0028862998

Web Of Science Accession Number


Start Page


  • 325

End Page


  • 327

Volume


  • 11

Issue


  • 3

Place Of Publication


Abstract


  • The influence of genetic factors in schizophrenia has been convincingly demonstrated by family, twin and adoption studies1���3, but the mode of transmission remains uncertain. The reported pattern of recurrence risks suggests a set of interacting loci4. Based on prior evidence for linkage on chromosome 6p (K. Kendler, pers. comm.), we have scanned the short arm of chromosome 6 in 54 families for loci predisposing to schizophrenia, using 25 microsatellite markers spanning 60 centiMorgans (cM). Allele sharing identity by descent was examined in affected sib-pairs from these families, followed by multipoint sib-pair linkage analysis. Positive lod scores were obtained over a wide region (D6S470 to D6S271), with a maximum lod score of 2.2 occuring near D6S274, located in 6p22. However, we obtained a lod score of ���2 at D6S296, the locus found by others to provide the greatest linkage evidence5. At D6S274, we report a positive lod score as do Straub et al.5 (individually non-significant). A combined total lod of 3.6���4.0 suggests the possibility of a susceptibility locus in this region. However, methodological differences between our studies makes a firm conclusion difficult. �� 1995 Nature Publishing Group.

Publication Date


  • 1995

Citation


  • Schwab, S. G., Albus, M., Hallmayer, J., H��nig, S., Borrmann, M., Lichtermann, D., . . . Wildenauer, D. B. (1995). Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib���pair linkage analysis. Nature Genetics, 11(3), 325-327. doi:10.1038/ng1195-325

Scopus Eid


  • 2-s2.0-0028862998

Web Of Science Accession Number


Start Page


  • 325

End Page


  • 327

Volume


  • 11

Issue


  • 3

Place Of Publication