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Serotonin transporter gene and schizophrenia: Evidence for association/linkage disequilibrium in families with affected siblings

Journal Article


Abstract


  • The serotonergic (5-HT) system has been implicated in the etiopathogenesis of psychoses. Since the 5-HT transporter plays an important role in regulation of 5-HT transmission, its gene can be considered as a candidate for vulnerability to psychiatric disorders. Two polymorphic sites of the 5-HT transporter gene - 5-HTTLPR, a VNTR in the 5' regulatory region, and a VNTR in the second intron - were studied in a sample of 61 families with schizophrenia for transmission disequilibrium. Each family contained at least two siblings affected with schizophrenia or schizoaffective disorder (mainly schizophrenic). One hundred and thirty-nine affected offspring with parental information for genotyping, were available for analysis. No preferential transmission of either short or long alleles of the promoter polymorphism was observed. However, a transmission distortion was detected for alleles of the intronic VNTR polymorphism (��2 (TDT) (max) = 14.33; P = 0.0002; corrected P value = 0.0003) resulting in more frequent than expected transmission of the 12 repeat allele. This finding adds additional evidence to the idea that the serotonergic system may be involved in development of psychoses.

Publication Date


  • 2000

Citation


  • Hranilovic, D., Schwab, S. G., Jernej, B., Knapp, M., Lerer, B., Albus, M., . . . Wildenauer, D. B. (2000). Serotonin transporter gene and schizophrenia: Evidence for association/linkage disequilibrium in families with affected siblings. Molecular Psychiatry, 5(1), 91-95. doi:10.1038/sj.mp.4000599

Scopus Eid


  • 2-s2.0-0033966436

Web Of Science Accession Number


Start Page


  • 91

End Page


  • 95

Volume


  • 5

Issue


  • 1

Place Of Publication


Abstract


  • The serotonergic (5-HT) system has been implicated in the etiopathogenesis of psychoses. Since the 5-HT transporter plays an important role in regulation of 5-HT transmission, its gene can be considered as a candidate for vulnerability to psychiatric disorders. Two polymorphic sites of the 5-HT transporter gene - 5-HTTLPR, a VNTR in the 5' regulatory region, and a VNTR in the second intron - were studied in a sample of 61 families with schizophrenia for transmission disequilibrium. Each family contained at least two siblings affected with schizophrenia or schizoaffective disorder (mainly schizophrenic). One hundred and thirty-nine affected offspring with parental information for genotyping, were available for analysis. No preferential transmission of either short or long alleles of the promoter polymorphism was observed. However, a transmission distortion was detected for alleles of the intronic VNTR polymorphism (��2 (TDT) (max) = 14.33; P = 0.0002; corrected P value = 0.0003) resulting in more frequent than expected transmission of the 12 repeat allele. This finding adds additional evidence to the idea that the serotonergic system may be involved in development of psychoses.

Publication Date


  • 2000

Citation


  • Hranilovic, D., Schwab, S. G., Jernej, B., Knapp, M., Lerer, B., Albus, M., . . . Wildenauer, D. B. (2000). Serotonin transporter gene and schizophrenia: Evidence for association/linkage disequilibrium in families with affected siblings. Molecular Psychiatry, 5(1), 91-95. doi:10.1038/sj.mp.4000599

Scopus Eid


  • 2-s2.0-0033966436

Web Of Science Accession Number


Start Page


  • 91

End Page


  • 95

Volume


  • 5

Issue


  • 1

Place Of Publication