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Multicenter linkage study of schizophrenia loci on chromosome 22q

Journal Article


Abstract


  • The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of 779 pedigrees. We also incorporated age at onset and sex into the analysis as covariates. No significant evidence for linkage to schizophrenia or for linkage associated with earlier age at onset, gender, or heterogeneity across sites was observed. We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkage analysis even in large samples.

Publication Date


  • 2004

Citation


  • Mowry, B. J., Holmans, P. A., Pulver, A. E., Gejman, P. V., Riley, B., Williams, N. M., . . . Levinson, D. F. (2004). Multicenter linkage study of schizophrenia loci on chromosome 22q. Molecular Psychiatry, 9(8), 784-795. doi:10.1038/sj.mp.4001481

Scopus Eid


  • 2-s2.0-4243053679

Web Of Science Accession Number


Start Page


  • 784

End Page


  • 795

Volume


  • 9

Issue


  • 8

Place Of Publication


Abstract


  • The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of 779 pedigrees. We also incorporated age at onset and sex into the analysis as covariates. No significant evidence for linkage to schizophrenia or for linkage associated with earlier age at onset, gender, or heterogeneity across sites was observed. We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkage analysis even in large samples.

Publication Date


  • 2004

Citation


  • Mowry, B. J., Holmans, P. A., Pulver, A. E., Gejman, P. V., Riley, B., Williams, N. M., . . . Levinson, D. F. (2004). Multicenter linkage study of schizophrenia loci on chromosome 22q. Molecular Psychiatry, 9(8), 784-795. doi:10.1038/sj.mp.4001481

Scopus Eid


  • 2-s2.0-4243053679

Web Of Science Accession Number


Start Page


  • 784

End Page


  • 795

Volume


  • 9

Issue


  • 8

Place Of Publication