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Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence

Journal Article


Abstract


  • Objective. - In a modified case-control association study we tested the assumption that two polymorphisms (A118G in exon 1 and IVS2+31 in intron 2) of the human ��-opioid receptor gene (OPRM1) confer susceptibility to opioid dependence. Methods. - In contrast to classical case-control studies both groups, opioid dependent cases and non-opioid dependent controls were recruited from individuals who have had access to drugs including opioids and who had been sentenced for violation of the "Dangerous Drugs Act" in Germany. Results. - For the two allelic variants of OPRM1 under study we did not find evidence for association with opioid dependence. Conclusions. - Despite absence of association we think that this recruitment approach introduced here, is useful since it putatively offers a more adequate matching for case-control association studies of opioid dependent individuals. �� 2003 ��ditions scientifiques et m��dicales Elsevier SAS. All rights reserved.

Publication Date


  • 2003

Citation


  • Franke, P., Wendel, B., Knapp, M., Schwab, S. G., Neef, D., Maier, W., . . . Hoehe, M. R. (2003). Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence. European Psychiatry, 18(1), 18-22. doi:10.1016/S0924-9338(02)00005-6

Scopus Eid


  • 2-s2.0-0346034819

Web Of Science Accession Number


Start Page


  • 18

End Page


  • 22

Volume


  • 18

Issue


  • 1

Place Of Publication


Abstract


  • Objective. - In a modified case-control association study we tested the assumption that two polymorphisms (A118G in exon 1 and IVS2+31 in intron 2) of the human ��-opioid receptor gene (OPRM1) confer susceptibility to opioid dependence. Methods. - In contrast to classical case-control studies both groups, opioid dependent cases and non-opioid dependent controls were recruited from individuals who have had access to drugs including opioids and who had been sentenced for violation of the "Dangerous Drugs Act" in Germany. Results. - For the two allelic variants of OPRM1 under study we did not find evidence for association with opioid dependence. Conclusions. - Despite absence of association we think that this recruitment approach introduced here, is useful since it putatively offers a more adequate matching for case-control association studies of opioid dependent individuals. �� 2003 ��ditions scientifiques et m��dicales Elsevier SAS. All rights reserved.

Publication Date


  • 2003

Citation


  • Franke, P., Wendel, B., Knapp, M., Schwab, S. G., Neef, D., Maier, W., . . . Hoehe, M. R. (2003). Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence. European Psychiatry, 18(1), 18-22. doi:10.1016/S0924-9338(02)00005-6

Scopus Eid


  • 2-s2.0-0346034819

Web Of Science Accession Number


Start Page


  • 18

End Page


  • 22

Volume


  • 18

Issue


  • 1

Place Of Publication