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DAT1 gene polymorphism in alcoholism: A family-based association study

Journal Article


Abstract


  • Background: The present study tests the hypothesis that the 9-repeat allele of the dopamine transporter gene (DAT1; SLC6A3) is more frequent in alcohol-dependent probands-and in particular those with severe withdrawal symptoms (seizures and/or delirium)-compared to nonalcoholics. Methods: To avoid stratification effects, the family-based association approach of Falk and Rubinstein was used in our sample of 87 alcohol-dependent probands and their biological parents. Results: By applying a family-based association approach, we were not able to detect significant association between allele 9 at DAT1 (SLC6A3) and alcoholism as well as between patients with or without severe withdrawal symptoms. Conclusions: Based on our data, the impact of the 9-repeat allele of the dopamine transporter gene in alcoholism and the severity of alcohol withdrawal symptoms is putatively not substantial.

Publication Date


  • 1999

Citation


  • Franke, P., Schwab, S. G., Knapp, M., G��nsicke, M., Delmo, C., Zill, P., . . . Maier, W. (1999). DAT1 gene polymorphism in alcoholism: A family-based association study. Biological Psychiatry, 45(5), 652-654. doi:10.1016/S0006-3223(98)00135-8

Scopus Eid


  • 2-s2.0-0033105228

Web Of Science Accession Number


Start Page


  • 652

End Page


  • 654

Volume


  • 45

Issue


  • 5

Place Of Publication


Abstract


  • Background: The present study tests the hypothesis that the 9-repeat allele of the dopamine transporter gene (DAT1; SLC6A3) is more frequent in alcohol-dependent probands-and in particular those with severe withdrawal symptoms (seizures and/or delirium)-compared to nonalcoholics. Methods: To avoid stratification effects, the family-based association approach of Falk and Rubinstein was used in our sample of 87 alcohol-dependent probands and their biological parents. Results: By applying a family-based association approach, we were not able to detect significant association between allele 9 at DAT1 (SLC6A3) and alcoholism as well as between patients with or without severe withdrawal symptoms. Conclusions: Based on our data, the impact of the 9-repeat allele of the dopamine transporter gene in alcoholism and the severity of alcohol withdrawal symptoms is putatively not substantial.

Publication Date


  • 1999

Citation


  • Franke, P., Schwab, S. G., Knapp, M., G��nsicke, M., Delmo, C., Zill, P., . . . Maier, W. (1999). DAT1 gene polymorphism in alcoholism: A family-based association study. Biological Psychiatry, 45(5), 652-654. doi:10.1016/S0006-3223(98)00135-8

Scopus Eid


  • 2-s2.0-0033105228

Web Of Science Accession Number


Start Page


  • 652

End Page


  • 654

Volume


  • 45

Issue


  • 5

Place Of Publication