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Potential linkage for schizophrenia on chromosome 22q12-q13: A replication study

Journal Article


Abstract


  • In an attempt to replicate a potential linkage on chromosome 22q12-q13.1 reported by Pulver et al. [1994: Am J Med Genet 54:36-43], we have analyzed 4 microsatellite markers which span this chromosomal region, including the IL2RB locus, for linkage with schizophrenia in 30 families from Israel and Germany. Linkage analysis by pairwise lod score analysis as well as by multipoint analysis did not provide evidence for a single major gene locus. However, a lod score of Z(max) = 0.612 was obtained for a dominant model of inheritance with the marker D22S304 at recombination fraction 0.2 by pairwise analysis. In addition, using a nonparametric method, sib pair analysis, a P value of 0.068 corresponding to a lod score of 0.48 was obtained for this marker. This finding, together with those of Pulver et al. [1994: Am J Med Genet 54:36-43] and Coon et al. [1994: Am J Med Genet 54:72-79], is suggestive of a genetic factor in this region, predisposing for schizophrenia in a subset of families. Further studies using nonparametric methods should be conducted in order to clarify this point.

Publication Date


  • 1995

Citation


  • Schwab, S. G., Lerer, B., Albus, M., Maier, W., Hallmayer, J., Fimmers, R., . . . Wildenauer, D. B. (1995). Potential linkage for schizophrenia on chromosome 22q12-q13: A replication study. American Journal of Medical Genetics - Neuropsychiatric Genetics, 60(5), 436-443. doi:10.1002/ajmg.1320600515

Scopus Eid


  • 2-s2.0-0028802764

Web Of Science Accession Number


Start Page


  • 436

End Page


  • 443

Volume


  • 60

Issue


  • 5

Place Of Publication


Abstract


  • In an attempt to replicate a potential linkage on chromosome 22q12-q13.1 reported by Pulver et al. [1994: Am J Med Genet 54:36-43], we have analyzed 4 microsatellite markers which span this chromosomal region, including the IL2RB locus, for linkage with schizophrenia in 30 families from Israel and Germany. Linkage analysis by pairwise lod score analysis as well as by multipoint analysis did not provide evidence for a single major gene locus. However, a lod score of Z(max) = 0.612 was obtained for a dominant model of inheritance with the marker D22S304 at recombination fraction 0.2 by pairwise analysis. In addition, using a nonparametric method, sib pair analysis, a P value of 0.068 corresponding to a lod score of 0.48 was obtained for this marker. This finding, together with those of Pulver et al. [1994: Am J Med Genet 54:36-43] and Coon et al. [1994: Am J Med Genet 54:72-79], is suggestive of a genetic factor in this region, predisposing for schizophrenia in a subset of families. Further studies using nonparametric methods should be conducted in order to clarify this point.

Publication Date


  • 1995

Citation


  • Schwab, S. G., Lerer, B., Albus, M., Maier, W., Hallmayer, J., Fimmers, R., . . . Wildenauer, D. B. (1995). Potential linkage for schizophrenia on chromosome 22q12-q13: A replication study. American Journal of Medical Genetics - Neuropsychiatric Genetics, 60(5), 436-443. doi:10.1002/ajmg.1320600515

Scopus Eid


  • 2-s2.0-0028802764

Web Of Science Accession Number


Start Page


  • 436

End Page


  • 443

Volume


  • 60

Issue


  • 5

Place Of Publication