Skip to main content
placeholder image

Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios

Journal Article


Abstract


  • A possible association between the small conductance calcium-regulated potassium channel gene, hSKCa3, and schizophrenia has recently been described by Chandy et al using a case-control design with patients with schizophrenia (n = 141) and matched controls (n = 158). The gene may be considered as an excellent candidate gene for psychiatric disorders, since it plays a role in modulating neuronal firing patterns by regulating the slow component of afterhyperpolarisation. In addition, the gene contains a highly polymorphic trinucleotide sequence (CAG) within exon 1, which encodes a polyglutamine stretch. The possible contribution of unstable trinucleotide repeats to the development of psychiatric disorders has previously been discussed. Chandy et al reported an over-representation of alleles with higher repeat number in schizophrenics as compared to controls (P = 0.0035). In an attempt to replicate these findings, we have performed a family-based study with 193 offspring/parent combinations using a sample of 49 multiplex families (two or more affected siblings with parents) and a second sample of 83 simplex families (one affected offspring with parents). No evidence for the association of longer repeats with schizophrenia was obtained when each sample was tested separately or when both samples were combined and tested for transmission disequilibrium.

Publication Date


  • 1999

Citation


  • Wittekindt, O., Schwab, S. G., Burgert, E., Knapp, M., Albus, M., Lerer, B., . . . Wildenauer, D. B. (1999). Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios. Molecular Psychiatry, 4(3), 267-270. doi:10.1038/sj.mp.4000495

Scopus Eid


  • 2-s2.0-0033009853

Web Of Science Accession Number


Start Page


  • 267

End Page


  • 270

Volume


  • 4

Issue


  • 3

Place Of Publication


Abstract


  • A possible association between the small conductance calcium-regulated potassium channel gene, hSKCa3, and schizophrenia has recently been described by Chandy et al using a case-control design with patients with schizophrenia (n = 141) and matched controls (n = 158). The gene may be considered as an excellent candidate gene for psychiatric disorders, since it plays a role in modulating neuronal firing patterns by regulating the slow component of afterhyperpolarisation. In addition, the gene contains a highly polymorphic trinucleotide sequence (CAG) within exon 1, which encodes a polyglutamine stretch. The possible contribution of unstable trinucleotide repeats to the development of psychiatric disorders has previously been discussed. Chandy et al reported an over-representation of alleles with higher repeat number in schizophrenics as compared to controls (P = 0.0035). In an attempt to replicate these findings, we have performed a family-based study with 193 offspring/parent combinations using a sample of 49 multiplex families (two or more affected siblings with parents) and a second sample of 83 simplex families (one affected offspring with parents). No evidence for the association of longer repeats with schizophrenia was obtained when each sample was tested separately or when both samples were combined and tested for transmission disequilibrium.

Publication Date


  • 1999

Citation


  • Wittekindt, O., Schwab, S. G., Burgert, E., Knapp, M., Albus, M., Lerer, B., . . . Wildenauer, D. B. (1999). Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios. Molecular Psychiatry, 4(3), 267-270. doi:10.1038/sj.mp.4000495

Scopus Eid


  • 2-s2.0-0033009853

Web Of Science Accession Number


Start Page


  • 267

End Page


  • 270

Volume


  • 4

Issue


  • 3

Place Of Publication