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Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis

Journal Article


Abstract


  • Suggestive evidence for a potential susceptibility locus for schizophrenia at 5q31 was obtained in two family samples. Sample I consisted of 14 families with schizophrenia and revealed for the marker IL9 a lod score of 1.8 by two point lod score analysis. Sample II comprised 44 families including four from sample I and was ascertained in order to employ affected sib-pair analysis by identity by descent. A lod score of 1.8 around the marker D5S399 was obtained by multipoint analysis. The lod score remained positive, but decreased to 1.27 when the four families from sample I were excluded in order to use sample II as a statistically independent replication sample. We propose a susceptibility locus for schizophrenia with probably minor contribution in the pedigrees under investigation.

Publication Date


  • 1997

Citation


  • Schwab, S. G., Eckstein, G. N., Hallmayer, J., Lerer, B., Albus, M., Borrmann, M., . . . Wildenauer, D. B. (1997). Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis. Molecular Psychiatry, 2(2), 156-160. doi:10.1038/sj.mp.4000263

Scopus Eid


  • 2-s2.0-8244226000

Web Of Science Accession Number


Start Page


  • 156

End Page


  • 160

Volume


  • 2

Issue


  • 2

Place Of Publication


Abstract


  • Suggestive evidence for a potential susceptibility locus for schizophrenia at 5q31 was obtained in two family samples. Sample I consisted of 14 families with schizophrenia and revealed for the marker IL9 a lod score of 1.8 by two point lod score analysis. Sample II comprised 44 families including four from sample I and was ascertained in order to employ affected sib-pair analysis by identity by descent. A lod score of 1.8 around the marker D5S399 was obtained by multipoint analysis. The lod score remained positive, but decreased to 1.27 when the four families from sample I were excluded in order to use sample II as a statistically independent replication sample. We propose a susceptibility locus for schizophrenia with probably minor contribution in the pedigrees under investigation.

Publication Date


  • 1997

Citation


  • Schwab, S. G., Eckstein, G. N., Hallmayer, J., Lerer, B., Albus, M., Borrmann, M., . . . Wildenauer, D. B. (1997). Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis. Molecular Psychiatry, 2(2), 156-160. doi:10.1038/sj.mp.4000263

Scopus Eid


  • 2-s2.0-8244226000

Web Of Science Accession Number


Start Page


  • 156

End Page


  • 160

Volume


  • 2

Issue


  • 2

Place Of Publication