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Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence

Journal Article


Abstract


  • The brain synaptic vesicular amine transporter SLCA18A2 is a key component for the uptake of monoamines like dopamine or serotonin into vesicles. We have analyzed seven DNA polymorphisms located in the genomic region of SLC18A2 for association with alcohol- and nicotine dependence, using a family-based design. Our sample comprised 131 families with alcohol-dependent offspring and 96 families with at least one nicotine-dependent offspring. For the alcohol-dependent sample, we found statistical significant association for two single markers (rs363387, P = 0.03; rs363333, P = 0.0066) as well as for several haplotypes (minimal P = 0.0038). When the sample with alcohol dependence was stratified according to gender, we observed increased association for the male subgroup (rs363387, P = 0.0011). None of the markers showed association in the sample of families with nicotine dependence. However, analysis of a combined sample of alcohol and nicotine-dependent families resulted in single markers as well as several haplotypes showing statistical significant association with substance dependence (minimal P = 0.0044). We conclude that DNA polymorphisms located in SLC18A2 might contribute to the development of substance dependence. �� 2005 Nature Publishing Group All rights reserved.

Publication Date


  • 2005

Citation


  • Schwab, S. G., Franke, P. E., Hoefgen, B., Guttenthaler, V., Lichtermann, D., Trixler, M., . . . Wildenauer, D. B. (2005). Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence. Neuropsychopharmacology, 30(12), 2263-2268. doi:10.1038/sj.npp.1300809

Scopus Eid


  • 2-s2.0-27844599733

Web Of Science Accession Number


Start Page


  • 2263

End Page


  • 2268

Volume


  • 30

Issue


  • 12

Place Of Publication


Abstract


  • The brain synaptic vesicular amine transporter SLCA18A2 is a key component for the uptake of monoamines like dopamine or serotonin into vesicles. We have analyzed seven DNA polymorphisms located in the genomic region of SLC18A2 for association with alcohol- and nicotine dependence, using a family-based design. Our sample comprised 131 families with alcohol-dependent offspring and 96 families with at least one nicotine-dependent offspring. For the alcohol-dependent sample, we found statistical significant association for two single markers (rs363387, P = 0.03; rs363333, P = 0.0066) as well as for several haplotypes (minimal P = 0.0038). When the sample with alcohol dependence was stratified according to gender, we observed increased association for the male subgroup (rs363387, P = 0.0011). None of the markers showed association in the sample of families with nicotine dependence. However, analysis of a combined sample of alcohol and nicotine-dependent families resulted in single markers as well as several haplotypes showing statistical significant association with substance dependence (minimal P = 0.0044). We conclude that DNA polymorphisms located in SLC18A2 might contribute to the development of substance dependence. �� 2005 Nature Publishing Group All rights reserved.

Publication Date


  • 2005

Citation


  • Schwab, S. G., Franke, P. E., Hoefgen, B., Guttenthaler, V., Lichtermann, D., Trixler, M., . . . Wildenauer, D. B. (2005). Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence. Neuropsychopharmacology, 30(12), 2263-2268. doi:10.1038/sj.npp.1300809

Scopus Eid


  • 2-s2.0-27844599733

Web Of Science Accession Number


Start Page


  • 2263

End Page


  • 2268

Volume


  • 30

Issue


  • 12

Place Of Publication