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Evaluation of association of SNPs in the TNF alpha gene region with schizophrenia

Journal Article


Abstract


  • The association of the tumor necrosis factor alpha (TNF��) -G308A promoter polymorphism with schizophrenia has complemented clinical findings of increased levels of the TNF�� cytokine in schizophrenic patients, with some support for a functional consequence of the variant. Our previous studies of genetic causes in schizophrenia supported findings of linkage to the major histocompatibility complex (MHC) region where the TNF�� gene is located as well as association with the -G308A promoter polymorphism. While the conrnion G-allele shows association in our sample, association with the A-allele has been reported by other groups. This suggests linkage disequilibrium (LB) rather than direct involvement in the disorder. In order to define LD of DNA variants with the disorder in this area, we analyzed 36 SNPs in a 165-kb region around this polymorphism. We detected nominally significant associations (P < 0.05) of three markers (including the -G308A promoter polymorphism) and multiple haplotypes with schizophrenia in our sample of 204 families (70 sib-pairs and 125 trios). The association is largely restricted to a 30 kb high LD region/block and should assist in the identification of a schizophrenia susceptibility gene within the block or elsewhere in the MHC. �� 2006 Wiley-Liss, Inc.

Publication Date


  • 2007

Citation


  • Morar, B., Schwab, S. G., Albus, M., Maier, W., Lerer, B., & Wildenauer, D. B. (2007). Evaluation of association of SNPs in the TNF alpha gene region with schizophrenia. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 144(3), 318-324. doi:10.1002/ajmg.b.30451

Scopus Eid


  • 2-s2.0-34247326401

Web Of Science Accession Number


Start Page


  • 318

End Page


  • 324

Volume


  • 144

Issue


  • 3

Place Of Publication


Abstract


  • The association of the tumor necrosis factor alpha (TNF��) -G308A promoter polymorphism with schizophrenia has complemented clinical findings of increased levels of the TNF�� cytokine in schizophrenic patients, with some support for a functional consequence of the variant. Our previous studies of genetic causes in schizophrenia supported findings of linkage to the major histocompatibility complex (MHC) region where the TNF�� gene is located as well as association with the -G308A promoter polymorphism. While the conrnion G-allele shows association in our sample, association with the A-allele has been reported by other groups. This suggests linkage disequilibrium (LB) rather than direct involvement in the disorder. In order to define LD of DNA variants with the disorder in this area, we analyzed 36 SNPs in a 165-kb region around this polymorphism. We detected nominally significant associations (P < 0.05) of three markers (including the -G308A promoter polymorphism) and multiple haplotypes with schizophrenia in our sample of 204 families (70 sib-pairs and 125 trios). The association is largely restricted to a 30 kb high LD region/block and should assist in the identification of a schizophrenia susceptibility gene within the block or elsewhere in the MHC. �� 2006 Wiley-Liss, Inc.

Publication Date


  • 2007

Citation


  • Morar, B., Schwab, S. G., Albus, M., Maier, W., Lerer, B., & Wildenauer, D. B. (2007). Evaluation of association of SNPs in the TNF alpha gene region with schizophrenia. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 144(3), 318-324. doi:10.1002/ajmg.b.30451

Scopus Eid


  • 2-s2.0-34247326401

Web Of Science Accession Number


Start Page


  • 318

End Page


  • 324

Volume


  • 144

Issue


  • 3

Place Of Publication