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No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population

Journal Article


Abstract


  • A polymorphism in intron 8 of the presenilin-1 (PS-1) gene has been demonstrated to increase the risk for developing late-onset Alzheimer disease (AD). Conflicting results exist for the association between this intronic polymorphism and AD probably due to variations in the PS-1 gene among different ethnic groups. We investigated the genetic association between this intronic polymorphism in the PS-1 gene and AD in a homogenous group of German Caucasians. The control group consisted of healthy subjects and depressed patients. There were no significant differences in the distribution of the PS-1 genotypes and allele frequencies between AD patients and controls. Our data do not support an association between the intronic polymorphism of the PS-1 gene and AD and there was no interaction between the PS-1 genotype and apolipoprotein E ��4 allele. Copyright (C) 1999 Elsevier Science B.V.

Publication Date


  • 1999

Citation


  • Bagli, M., Papassotiropoulos, A., Schwab, S. G., Lessen, F., Rao, M. L., Maier, W., & Heun, R. (1999). No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population. Journal of the Neurological Sciences, 167(1), 34-36. doi:10.1016/S0022-510X(99)00131-8

Scopus Eid


  • 2-s2.0-0032793810

Web Of Science Accession Number


Start Page


  • 34

End Page


  • 36

Volume


  • 167

Issue


  • 1

Place Of Publication


Abstract


  • A polymorphism in intron 8 of the presenilin-1 (PS-1) gene has been demonstrated to increase the risk for developing late-onset Alzheimer disease (AD). Conflicting results exist for the association between this intronic polymorphism and AD probably due to variations in the PS-1 gene among different ethnic groups. We investigated the genetic association between this intronic polymorphism in the PS-1 gene and AD in a homogenous group of German Caucasians. The control group consisted of healthy subjects and depressed patients. There were no significant differences in the distribution of the PS-1 genotypes and allele frequencies between AD patients and controls. Our data do not support an association between the intronic polymorphism of the PS-1 gene and AD and there was no interaction between the PS-1 genotype and apolipoprotein E ��4 allele. Copyright (C) 1999 Elsevier Science B.V.

Publication Date


  • 1999

Citation


  • Bagli, M., Papassotiropoulos, A., Schwab, S. G., Lessen, F., Rao, M. L., Maier, W., & Heun, R. (1999). No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population. Journal of the Neurological Sciences, 167(1), 34-36. doi:10.1016/S0022-510X(99)00131-8

Scopus Eid


  • 2-s2.0-0032793810

Web Of Science Accession Number


Start Page


  • 34

End Page


  • 36

Volume


  • 167

Issue


  • 1

Place Of Publication