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Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

Journal Article


Abstract


  • A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

Publication Date


  • 2001

Citation


  • Sklar, P., Schwab, S. G., Williams, N. M., Daly, M., Schaffner, S., Maier, W., . . . Wildenauer, D. B. (2001). Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls. Nature Genetics, 28(2), 126-128. doi:10.1038/88836

Scopus Eid


  • 2-s2.0-0034975491

Web Of Science Accession Number


Start Page


  • 126

End Page


  • 128

Volume


  • 28

Issue


  • 2

Place Of Publication


Abstract


  • A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

Publication Date


  • 2001

Citation


  • Sklar, P., Schwab, S. G., Williams, N. M., Daly, M., Schaffner, S., Maier, W., . . . Wildenauer, D. B. (2001). Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls. Nature Genetics, 28(2), 126-128. doi:10.1038/88836

Scopus Eid


  • 2-s2.0-0034975491

Web Of Science Accession Number


Start Page


  • 126

End Page


  • 128

Volume


  • 28

Issue


  • 2

Place Of Publication