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[No Association of the - 141C Ins/Del Polymorphism of the Dopamine D2 Receptor with Schizophrenia]

Journal Article


Abstract


  • Recently, a putative functional polymorphism (- 141C Ins/Del) in the 5'-flanking region of the dopamine D (2) receptor was found. An association of the Ins allele with schizophrenia has been described in a Japanese sample. In the present study this association was examined in a German schizophrenia patient population. In a family based approach 190 German family trios were analyzed for the - 141C Ins/Del genotype. Using the transmission disequilibrium test (TDT) we found no evidence for an association of the Ins allele with schizophrenia (TDT = 0.152, P = 0.696). In parallel, we performed an independent case control study with 268 schizophrenic patients and 244 controls. Again, we did not detect an overrepresentation of the Ins allele in patients (P = 0.124). Thus, our data do not support the hypothesis that the - 141C Ins variant plays a major role in predisposition to schizophrenia. To confirm our conclusion further preferentially family based studies are needed.

Publication Date


  • 2003

Citation


  • Rohrmeier, T., Putzhammer, A., Sartor, H., Knapp, M., Albus, M., Borrmann-Hassenbach, M., . . . Eichhammer, P. (2003). [No Association of the - 141C Ins/Del Polymorphism of the Dopamine D2 Receptor with Schizophrenia]. Psychiatrische Praxis, 30(Suppl 2), 212-215. doi:10.1055/s-2003-39757

Web Of Science Accession Number


Start Page


  • 212

End Page


  • 215

Volume


  • 30

Issue


  • Suppl 2

Place Of Publication


Abstract


  • Recently, a putative functional polymorphism (- 141C Ins/Del) in the 5'-flanking region of the dopamine D (2) receptor was found. An association of the Ins allele with schizophrenia has been described in a Japanese sample. In the present study this association was examined in a German schizophrenia patient population. In a family based approach 190 German family trios were analyzed for the - 141C Ins/Del genotype. Using the transmission disequilibrium test (TDT) we found no evidence for an association of the Ins allele with schizophrenia (TDT = 0.152, P = 0.696). In parallel, we performed an independent case control study with 268 schizophrenic patients and 244 controls. Again, we did not detect an overrepresentation of the Ins allele in patients (P = 0.124). Thus, our data do not support the hypothesis that the - 141C Ins variant plays a major role in predisposition to schizophrenia. To confirm our conclusion further preferentially family based studies are needed.

Publication Date


  • 2003

Citation


  • Rohrmeier, T., Putzhammer, A., Sartor, H., Knapp, M., Albus, M., Borrmann-Hassenbach, M., . . . Eichhammer, P. (2003). [No Association of the - 141C Ins/Del Polymorphism of the Dopamine D2 Receptor with Schizophrenia]. Psychiatrische Praxis, 30(Suppl 2), 212-215. doi:10.1055/s-2003-39757

Web Of Science Accession Number


Start Page


  • 212

End Page


  • 215

Volume


  • 30

Issue


  • Suppl 2

Place Of Publication