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Investigation of linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB 1-, AND DRB1-alleles in 69 sib-pair- and 89 trio-families with schizophrenia

Journal Article


Abstract


  • The hypothesis that HLA antigens confer susceptibility to schizophrenic disorders has been tested by studying linkage and association in a family sample with 69 sib-pair families. Suggestive evidence for linkage was obtained by nonparametric multipoint LOD score analysis with a maximum around DQB CAR (P = 0.0004), a microsatellite marker that is in linkage disequilibrium with the HLA antigen DQB1. Spurious evidence for negative association as calculated by the transmission disequilibrium test was found for HLA- DRB1*11 (chi-square = 11.72, corrected P value = 0.03) and for the haplotype DQB1*301-DQA1*501-DRB1*11 (chisquare = 11.3, corrected P value = 0.043). No evidence of association with these alleles was obtained in a sample of 89 trios with schizophrenic offspring and parents. Our results are not in favor of a direct involvement of the HLA system in development of schizophrenia, but are compatible with the possible existence of a susceptibility gene in the MHC region at chromosome 6p 21.31. �� 2002 Wiley-Liss, Inc.

Publication Date


  • 2002

Citation


  • Schwab, S. G., Hallmayer, J., Freimann, J., Lerer, B., Albus, M., Borrmann-Hassenbach, M., . . . Wildenauer, D. B. (2002). Investigation of linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB 1-, AND DRB1-alleles in 69 sib-pair- and 89 trio-families with schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics, 114(3), 315-320. doi:10.1002/ajmg.10307

Scopus Eid


  • 2-s2.0-0012284588

Web Of Science Accession Number


Start Page


  • 315

End Page


  • 320

Volume


  • 114

Issue


  • 3

Place Of Publication


Abstract


  • The hypothesis that HLA antigens confer susceptibility to schizophrenic disorders has been tested by studying linkage and association in a family sample with 69 sib-pair families. Suggestive evidence for linkage was obtained by nonparametric multipoint LOD score analysis with a maximum around DQB CAR (P = 0.0004), a microsatellite marker that is in linkage disequilibrium with the HLA antigen DQB1. Spurious evidence for negative association as calculated by the transmission disequilibrium test was found for HLA- DRB1*11 (chi-square = 11.72, corrected P value = 0.03) and for the haplotype DQB1*301-DQA1*501-DRB1*11 (chisquare = 11.3, corrected P value = 0.043). No evidence of association with these alleles was obtained in a sample of 89 trios with schizophrenic offspring and parents. Our results are not in favor of a direct involvement of the HLA system in development of schizophrenia, but are compatible with the possible existence of a susceptibility gene in the MHC region at chromosome 6p 21.31. �� 2002 Wiley-Liss, Inc.

Publication Date


  • 2002

Citation


  • Schwab, S. G., Hallmayer, J., Freimann, J., Lerer, B., Albus, M., Borrmann-Hassenbach, M., . . . Wildenauer, D. B. (2002). Investigation of linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB 1-, AND DRB1-alleles in 69 sib-pair- and 89 trio-families with schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics, 114(3), 315-320. doi:10.1002/ajmg.10307

Scopus Eid


  • 2-s2.0-0012284588

Web Of Science Accession Number


Start Page


  • 315

End Page


  • 320

Volume


  • 114

Issue


  • 3

Place Of Publication