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Molecular genetics of schizophrenia

Journal Article


Abstract


  • Schizophrenia is aggregated in families because of underlying genetic factors. The application of efficient molecular-genetic techniques have produced findings of several linkages on the genome, with independent replications on chromosomes 5q, 6p, 8p, 13q and 22q. Susceptibility genes are probably localized in these regions and have to be identified. The multiplicity of suggestive regions showing linkage to schizophrenia argues against a single causal or major operating gene for schizophrenia. Despite replications, the observed strength of linkages is modest, as is the strength of associations. These observations suggest that the effect sizes of the single susceptibility genes are small, that complex interactions with environmental factors are operating, or both.

Publication Date


  • 1998

Citation


  • Maier, W., & Schwab, S. (1998). Molecular genetics of schizophrenia. Current Opinion in Psychiatry, 11(1), 19-25. doi:10.1097/00001504-199801000-00014

Scopus Eid


  • 2-s2.0-0031975818

Web Of Science Accession Number


Start Page


  • 19

End Page


  • 25

Volume


  • 11

Issue


  • 1

Abstract


  • Schizophrenia is aggregated in families because of underlying genetic factors. The application of efficient molecular-genetic techniques have produced findings of several linkages on the genome, with independent replications on chromosomes 5q, 6p, 8p, 13q and 22q. Susceptibility genes are probably localized in these regions and have to be identified. The multiplicity of suggestive regions showing linkage to schizophrenia argues against a single causal or major operating gene for schizophrenia. Despite replications, the observed strength of linkages is modest, as is the strength of associations. These observations suggest that the effect sizes of the single susceptibility genes are small, that complex interactions with environmental factors are operating, or both.

Publication Date


  • 1998

Citation


  • Maier, W., & Schwab, S. (1998). Molecular genetics of schizophrenia. Current Opinion in Psychiatry, 11(1), 19-25. doi:10.1097/00001504-199801000-00014

Scopus Eid


  • 2-s2.0-0031975818

Web Of Science Accession Number


Start Page


  • 19

End Page


  • 25

Volume


  • 11

Issue


  • 1