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No major schizophrenia locus detected on chromosome 1q in a large multicenter sample

Journal Article


Abstract


  • Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.

Publication Date


  • 2002

Citation


  • Levinson, D. F., Holmans, P. A., Laurent, C., Riley, B., Pulver, A. E., Gejman, P. V., . . . Walters, M. (2002). No major schizophrenia locus detected on chromosome 1q in a large multicenter sample. Science, 296(5568), 739-741. doi:10.1126/science.1069914

Scopus Eid


  • 2-s2.0-18344389404

Web Of Science Accession Number


Start Page


  • 739

End Page


  • 741

Volume


  • 296

Issue


  • 5568

Place Of Publication


Abstract


  • Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.

Publication Date


  • 2002

Citation


  • Levinson, D. F., Holmans, P. A., Laurent, C., Riley, B., Pulver, A. E., Gejman, P. V., . . . Walters, M. (2002). No major schizophrenia locus detected on chromosome 1q in a large multicenter sample. Science, 296(5568), 739-741. doi:10.1126/science.1069914

Scopus Eid


  • 2-s2.0-18344389404

Web Of Science Accession Number


Start Page


  • 739

End Page


  • 741

Volume


  • 296

Issue


  • 5568

Place Of Publication