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Incoherent elastic neutron scattering as a function of temperature: A fast way to characterize in-situ biological dynamics in complex solutions

Journal Article


Abstract


  • Thermal motions in macromolecules have been shown to be highly relevant in biology, allowing, for example, functionally important conformational changes to occur on much longer time-scales. Because of the values of their associated wavelengths and energies, thermal and cold neutrons are uniquely suitable for the characterization of these confined pico- to nano-second motions. Information useful to furthering understanding in biology, however, is mostly derived from measurements on many different systems under various conditions. Incoherent elastic neutron scattering temperature scans allow rapid screening of samples and conditions. The power of the method is demonstrated by recent results on proteins in solution and complex biological systems.

Publication Date


  • 2000

Citation


  • Zaccai, G., Tehei, M., Scherbakova, I., Serdyuk, I., Gerez, C., & Pfister, C. (2000). Incoherent elastic neutron scattering as a function of temperature: A fast way to characterize in-situ biological dynamics in complex solutions. Journal De Physique. IV : JP, 10(7).

Scopus Eid


  • 2-s2.0-0033683008

Web Of Science Accession Number


Volume


  • 10

Issue


  • 7

Abstract


  • Thermal motions in macromolecules have been shown to be highly relevant in biology, allowing, for example, functionally important conformational changes to occur on much longer time-scales. Because of the values of their associated wavelengths and energies, thermal and cold neutrons are uniquely suitable for the characterization of these confined pico- to nano-second motions. Information useful to furthering understanding in biology, however, is mostly derived from measurements on many different systems under various conditions. Incoherent elastic neutron scattering temperature scans allow rapid screening of samples and conditions. The power of the method is demonstrated by recent results on proteins in solution and complex biological systems.

Publication Date


  • 2000

Citation


  • Zaccai, G., Tehei, M., Scherbakova, I., Serdyuk, I., Gerez, C., & Pfister, C. (2000). Incoherent elastic neutron scattering as a function of temperature: A fast way to characterize in-situ biological dynamics in complex solutions. Journal De Physique. IV : JP, 10(7).

Scopus Eid


  • 2-s2.0-0033683008

Web Of Science Accession Number


Volume


  • 10

Issue


  • 7