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A spatial statistical analysis of tumor growth

Journal Article


Abstract


  • Growth models for tumors commonly are developed for a one-dimensional summary (e.g., number of cells, volume). At the supracellular level, however, ignoring tumor shape leads to oversimplification of the growth mechanism. For example, an oncologist would view the discovery of a compact tumor of volume v differently from the discovery of two osculatory compact tumors each of volume v/2. This article presents a growth model that uses shape information at a previous time to describe the tumor at the present time. An analysis is given of three successive two-dimensional images of cell islands, which are obtained from in vitro growth of human breast cancer cells. © 1992 Taylor & Francis Group, LLC.

Publication Date


  • 1992

Citation


  • Cressie, N., & Hulting, F. L. (1992). A spatial statistical analysis of tumor growth. Journal of the American Statistical Association, 87(418), 272-283. doi:10.1080/01621459.1992.10475206

Scopus Eid


  • 2-s2.0-84950433304

Web Of Science Accession Number


Start Page


  • 272

End Page


  • 283

Volume


  • 87

Issue


  • 418

Abstract


  • Growth models for tumors commonly are developed for a one-dimensional summary (e.g., number of cells, volume). At the supracellular level, however, ignoring tumor shape leads to oversimplification of the growth mechanism. For example, an oncologist would view the discovery of a compact tumor of volume v differently from the discovery of two osculatory compact tumors each of volume v/2. This article presents a growth model that uses shape information at a previous time to describe the tumor at the present time. An analysis is given of three successive two-dimensional images of cell islands, which are obtained from in vitro growth of human breast cancer cells. © 1992 Taylor & Francis Group, LLC.

Publication Date


  • 1992

Citation


  • Cressie, N., & Hulting, F. L. (1992). A spatial statistical analysis of tumor growth. Journal of the American Statistical Association, 87(418), 272-283. doi:10.1080/01621459.1992.10475206

Scopus Eid


  • 2-s2.0-84950433304

Web Of Science Accession Number


Start Page


  • 272

End Page


  • 283

Volume


  • 87

Issue


  • 418