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Dynamic baroreflex control of blood pressure: influence of the heart vs. peripheral resistance.

Journal Article


Abstract


  • The aim in the present experiments was to assess the dynamic baroreflex control of blood pressure, to develop an accurate mathematical model that represented this relationship, and to assess the role of dynamic changes in heart rate and stroke volume in giving rise to components of this response. Patterned electrical stimulation [pseudo-random binary sequence (PRBS)] was applied to the aortic depressor nerve (ADN) to produce changes in blood pressure under open-loop conditions in anesthetized rabbits. The stimulus provided constant power over the frequency range 0-0.5 Hz and revealed that the composite systems represented by the central nervous system, sympathetic activity, and vascular resistance responded as a second-order low-pass filter (corner frequency approximately 0.047 Hz) with a time delay (1.01 s). The gain between ADN and mean arterial pressure was reasonably constant before the corner frequency and then decreased with increasing frequency of stimulus. Although the heart rate was altered in response to the PRBS stimuli, we found that removal of the heart's ability to contribute to blood pressure variability by vagotomy and beta(1)-receptor blockade did not significantly alter the frequency response. We conclude that the contribution of the heart to the dynamic regulation of blood pressure is negligible in the rabbit. The consequences of this finding are examined with respect to low-frequency oscillations in blood pressure.

Publication Date


  • 2002

Citation


  • Liu, H. -K., Guild, S. -J., Ringwood, J. V., Barrett, C. J., Leonard, B. L., Nguang, S. -K., . . . Malpas, S. C. (2002). Dynamic baroreflex control of blood pressure: influence of the heart vs. peripheral resistance.. American journal of physiology. Regulatory, integrative and comparative physiology, 283(2), R533-R542. doi:10.1152/ajpregu.00489.2001

Web Of Science Accession Number


Start Page


  • R533

End Page


  • R542

Volume


  • 283

Issue


  • 2

Abstract


  • The aim in the present experiments was to assess the dynamic baroreflex control of blood pressure, to develop an accurate mathematical model that represented this relationship, and to assess the role of dynamic changes in heart rate and stroke volume in giving rise to components of this response. Patterned electrical stimulation [pseudo-random binary sequence (PRBS)] was applied to the aortic depressor nerve (ADN) to produce changes in blood pressure under open-loop conditions in anesthetized rabbits. The stimulus provided constant power over the frequency range 0-0.5 Hz and revealed that the composite systems represented by the central nervous system, sympathetic activity, and vascular resistance responded as a second-order low-pass filter (corner frequency approximately 0.047 Hz) with a time delay (1.01 s). The gain between ADN and mean arterial pressure was reasonably constant before the corner frequency and then decreased with increasing frequency of stimulus. Although the heart rate was altered in response to the PRBS stimuli, we found that removal of the heart's ability to contribute to blood pressure variability by vagotomy and beta(1)-receptor blockade did not significantly alter the frequency response. We conclude that the contribution of the heart to the dynamic regulation of blood pressure is negligible in the rabbit. The consequences of this finding are examined with respect to low-frequency oscillations in blood pressure.

Publication Date


  • 2002

Citation


  • Liu, H. -K., Guild, S. -J., Ringwood, J. V., Barrett, C. J., Leonard, B. L., Nguang, S. -K., . . . Malpas, S. C. (2002). Dynamic baroreflex control of blood pressure: influence of the heart vs. peripheral resistance.. American journal of physiology. Regulatory, integrative and comparative physiology, 283(2), R533-R542. doi:10.1152/ajpregu.00489.2001

Web Of Science Accession Number


Start Page


  • R533

End Page


  • R542

Volume


  • 283

Issue


  • 2