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Oxygen consumption and sodium pump thermogenesis in a developing mammal

Journal Article


Abstract


  • During development the liver undergoes large changes in its oxygen consumption. The energy requirements of the sodium pump (i.e., ouabain-sensitive respiration) would appear to account for a major part of these changes. In very young rats (birth to 9 days), the sodium pump accounted for ~50% of a high weight-specific liver metabolism (LMR). In rats ≥20 days of age, the sodium pump accounted for a smaller percentage (33%) of a much lower LMR. These changes scaled with body mass. LMR scaled with an allometric slope of -0.258, ouabain-sensitive respiration with a slope of -0.355, and ouabain-insensitive respiration with a slope of -0.194. It is proposed that changes in LMR of rats during development are due primarily to the changing energy requirements of the sodium pump.

Publication Date


  • 1991

Citation


  • Else, P. L. (1991). Oxygen consumption and sodium pump thermogenesis in a developing mammal. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 261(6 30-6). doi:10.1152/ajpregu.1991.261.6.r1575

Scopus Eid


  • 2-s2.0-0026332917

Volume


  • 261

Issue


  • 6 30-6

Abstract


  • During development the liver undergoes large changes in its oxygen consumption. The energy requirements of the sodium pump (i.e., ouabain-sensitive respiration) would appear to account for a major part of these changes. In very young rats (birth to 9 days), the sodium pump accounted for ~50% of a high weight-specific liver metabolism (LMR). In rats ≥20 days of age, the sodium pump accounted for a smaller percentage (33%) of a much lower LMR. These changes scaled with body mass. LMR scaled with an allometric slope of -0.258, ouabain-sensitive respiration with a slope of -0.355, and ouabain-insensitive respiration with a slope of -0.194. It is proposed that changes in LMR of rats during development are due primarily to the changing energy requirements of the sodium pump.

Publication Date


  • 1991

Citation


  • Else, P. L. (1991). Oxygen consumption and sodium pump thermogenesis in a developing mammal. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 261(6 30-6). doi:10.1152/ajpregu.1991.261.6.r1575

Scopus Eid


  • 2-s2.0-0026332917

Volume


  • 261

Issue


  • 6 30-6