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Effect of He-Ne laser on brain injury after hypoxia-ischemia in newborn rats

Journal Article


Abstract


  • Aim: To study the role and possible mechanism of He-Ne laser acupoint irradiation treatment on hypoxia ischemia brain damage (HIBD). Methods: Forty-two Wistar rats, 7 days of age, were randomized into sham-operation group, HIBD group and He-Ne laser acupoint irradiation group (laser group). Twenty-two days later, left brains were taken out and made into paraffin sections. Immunohistochemical staining was performed with choline acetyltransferase (ChAT) and brain-derived neurotrophic factor(BDNF). Results: He-Ne laser acupoint irradiation was effective in inhibiting the loss of Nissl bodies in brain tissue and promoting the expression of ChAT and BDNF in brain tissue after hypoxia-ischemia. Conclusion: He-Ne laser acupoint irradiation has a neuroprotective effect on brain after hypoxia-ischemia, and its action mechanism may be related to the expression of BDNF.

Publication Date


  • 2004

Citation


  • Liu, W., Wu, A. Q., Li, W. Q., Gao, Y., Zhang, H., & Tang, S. J. (2004). Effect of He-Ne laser on brain injury after hypoxia-ischemia in newborn rats. Chinese Journal of Clinical Rehabilitation, 8(16), 3058-3059.

Scopus Eid


  • 2-s2.0-3543138236

Web Of Science Accession Number


Start Page


  • 3058

End Page


  • 3059

Volume


  • 8

Issue


  • 16

Abstract


  • Aim: To study the role and possible mechanism of He-Ne laser acupoint irradiation treatment on hypoxia ischemia brain damage (HIBD). Methods: Forty-two Wistar rats, 7 days of age, were randomized into sham-operation group, HIBD group and He-Ne laser acupoint irradiation group (laser group). Twenty-two days later, left brains were taken out and made into paraffin sections. Immunohistochemical staining was performed with choline acetyltransferase (ChAT) and brain-derived neurotrophic factor(BDNF). Results: He-Ne laser acupoint irradiation was effective in inhibiting the loss of Nissl bodies in brain tissue and promoting the expression of ChAT and BDNF in brain tissue after hypoxia-ischemia. Conclusion: He-Ne laser acupoint irradiation has a neuroprotective effect on brain after hypoxia-ischemia, and its action mechanism may be related to the expression of BDNF.

Publication Date


  • 2004

Citation


  • Liu, W., Wu, A. Q., Li, W. Q., Gao, Y., Zhang, H., & Tang, S. J. (2004). Effect of He-Ne laser on brain injury after hypoxia-ischemia in newborn rats. Chinese Journal of Clinical Rehabilitation, 8(16), 3058-3059.

Scopus Eid


  • 2-s2.0-3543138236

Web Of Science Accession Number


Start Page


  • 3058

End Page


  • 3059

Volume


  • 8

Issue


  • 16