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Biological Markers and Schizophrenia

Journal Article


Abstract


  • Objective: The delivery of biological markers for schizophrenia would greatly assist preventative strategies by identifying at-risk individuals who could then be monitored and treated in a manner with a view to minimising subsequent morbidity. This paper aims to present a selection of biological measures that may indicate risk of schizophrenia. Method: A selective and brief review is provided of intensively studied putative markers, including enlarged cerebral ventricles, dopamine D2 receptor density, amphetamine-stimulated central nervous system dopamine release, plasma homovanillic acid and smooth pursuit eye tracking dysfunction. Results: A number of biological measures have been reported to be correlated with schizophrenia. Conclusions: Presently, none of these measures has satisfactory performance characteristics in terms of predictive validity, noninvasiveness, ease of testing and low cost that would enable their widespread use. However, a few have potential for further investigation and development. © 2000, The Royal Australian and New Zealand College of Psychiatrists. All rights reserved.

Publication Date


  • 2000

Citation


  • Copolov, D., & Crook, J. (2000). Biological Markers and Schizophrenia. Australian and New Zealand Journal of Psychiatry, 34, S108-S112. doi:10.1080/000486700230

Scopus Eid


  • 2-s2.0-0034321753

Start Page


  • S108

End Page


  • S112

Volume


  • 34

Abstract


  • Objective: The delivery of biological markers for schizophrenia would greatly assist preventative strategies by identifying at-risk individuals who could then be monitored and treated in a manner with a view to minimising subsequent morbidity. This paper aims to present a selection of biological measures that may indicate risk of schizophrenia. Method: A selective and brief review is provided of intensively studied putative markers, including enlarged cerebral ventricles, dopamine D2 receptor density, amphetamine-stimulated central nervous system dopamine release, plasma homovanillic acid and smooth pursuit eye tracking dysfunction. Results: A number of biological measures have been reported to be correlated with schizophrenia. Conclusions: Presently, none of these measures has satisfactory performance characteristics in terms of predictive validity, noninvasiveness, ease of testing and low cost that would enable their widespread use. However, a few have potential for further investigation and development. © 2000, The Royal Australian and New Zealand College of Psychiatrists. All rights reserved.

Publication Date


  • 2000

Citation


  • Copolov, D., & Crook, J. (2000). Biological Markers and Schizophrenia. Australian and New Zealand Journal of Psychiatry, 34, S108-S112. doi:10.1080/000486700230

Scopus Eid


  • 2-s2.0-0034321753

Start Page


  • S108

End Page


  • S112

Volume


  • 34