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Event-related fMRI responses in the human frontal eye fields in a randomized pro- and antisaccade task

Journal Article


Abstract


  • We examined whether the frontal eye fields (FEF) are involved in the suppression of reflexive saccades. Simultaneous recording of horizontal eye movements and functional magnetic resonance imaging enabled us to perform a randomized pro- and antisaccade task and to sort blood oxygenation level dependent (BOLD) time series on the basis of task performance. Saccadic reaction time distributions were comparable across tasks indicating a similar effort in preprocessing of the saccades. Furthermore, we found similar BOLD activation in FEF during both correctly performed pro- and antisaccades. Frontal eye field activation started prior to target presentation and saccade generation. While we observed only few erroneous antisaccades, these were associated with a decrease in BOLD activity prior to target presentation, and increased BOLD activity after target presentation relative to correctly performed antisaccades. These findings are consistent with a role of the FEF in the suppression of reflexive saccades. The increase in activity after target presentation for antisaccade errors can only be indirectly linked to such a role but may also reflect activity related to the generation of a correction saccade. Frontal eye field BOLD activity may further represent general arousal, preparatory set, short-term memory, or salience-map related activity.

Publication Date


  • 2002

Citation


  • Cornelissen, F. W., Kimmig, H., Schira, M., Rutschmann, R. M., Maguire, P. R., Broerse, A., . . . Greenlee, M. W. (2002). Event-related fMRI responses in the human frontal eye fields in a randomized pro- and antisaccade task. Experimental Brain Research, 145(2), 270-274. doi:10.1007/s00221-002-1136-3

Scopus Eid


  • 2-s2.0-0036308490

Start Page


  • 270

End Page


  • 274

Volume


  • 145

Issue


  • 2

Abstract


  • We examined whether the frontal eye fields (FEF) are involved in the suppression of reflexive saccades. Simultaneous recording of horizontal eye movements and functional magnetic resonance imaging enabled us to perform a randomized pro- and antisaccade task and to sort blood oxygenation level dependent (BOLD) time series on the basis of task performance. Saccadic reaction time distributions were comparable across tasks indicating a similar effort in preprocessing of the saccades. Furthermore, we found similar BOLD activation in FEF during both correctly performed pro- and antisaccades. Frontal eye field activation started prior to target presentation and saccade generation. While we observed only few erroneous antisaccades, these were associated with a decrease in BOLD activity prior to target presentation, and increased BOLD activity after target presentation relative to correctly performed antisaccades. These findings are consistent with a role of the FEF in the suppression of reflexive saccades. The increase in activity after target presentation for antisaccade errors can only be indirectly linked to such a role but may also reflect activity related to the generation of a correction saccade. Frontal eye field BOLD activity may further represent general arousal, preparatory set, short-term memory, or salience-map related activity.

Publication Date


  • 2002

Citation


  • Cornelissen, F. W., Kimmig, H., Schira, M., Rutschmann, R. M., Maguire, P. R., Broerse, A., . . . Greenlee, M. W. (2002). Event-related fMRI responses in the human frontal eye fields in a randomized pro- and antisaccade task. Experimental Brain Research, 145(2), 270-274. doi:10.1007/s00221-002-1136-3

Scopus Eid


  • 2-s2.0-0036308490

Start Page


  • 270

End Page


  • 274

Volume


  • 145

Issue


  • 2