SHRIMP U-Pb zircon ages are reported from a paragneiss, a pegmatite, a metasomatised metasediment and an amphibolite taken from the upper amphibolite facies host sequence of the Cannington Ag-Pb-Zn deposit at the southeastern margin of the Proterozoic Mt Isa Block. Also reported are ages from a middle amphibolite-facies metasediment from the Soldiers Cap Group approximately 90 km north of Cannington. The predominantly metasedimentary host rocks of the Cannington deposit were eroded from a terrane containing latest Archaean to earliest Palaeoproterozoic (ca 2600-2300 Ma) and Palaeoproterozoic (ca 1750-1700 Ma) zircon. The ca 1750-1700 Ma group of zircons are consistent with sedimentary provenance from rocks of Cover Sequence 2 age that are now exposed to the north and west of the Cannington deposit. The metasedimentary samples also include a group of zircon grains at ca 1675 Ma, which we interpret as the maximum depositional age of the sedimentary protolith. This is comparable to the maximum depositional age of the metasediment from the Maronan area (ca 1665 Ma) and to previously published data from the Soldiers Cap Group. Metamorphic zircon rims and new zircon grains grew at 1600-1580 Ma during upper amphibolite-facies metamorphism in metasedimentary and mafic magmatic rocks. Zircon inheritance patterns suggest that sheet-like pegmatitic intrusions were most likely derived from partial melting of the surrounding metasediments during this period of metamorphism. Some zircon grains from the amphibolite have a morphology consistent with partially recrystallised igneous grains and have apparent ages close to the metamorphic age, although it is not clear whether these represent metamorphic resetting or crystallisation of the magmatic protolith. Pb-loss during syn- to post-metamorphic metasomatism resulted in partial resetting of zircons from the metasomatised metasediment.