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Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase

Journal Article


Abstract


  • Human theta-class glutathione S-transferases (GST's) appear to play a critical role in the metabolism of a variety of environmental pollutants but in some cases the products of the reaction are carcinogenic. Crystals of a human theta-class GST, namely hGSTT2-2, have been grown from polyethylene glycol by the hanging-drop vapour-diffusion method. The crystals belong to the trigonal space group P3121 with cell dimensions of a= b = 94.0 and c = 120.5 Å. They contain two monomers in the asymmetric unit and diffract to 3.0 Å resolution.

Publication Date


  • 1998

Citation


  • Mckinstry, W. J., Oakley, A. J., Rossjohn, J., Verger, D., Tan, K. L., Board, P. G., & Parker, M. W. (1998). Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase. Acta Crystallographica Section D: Biological Crystallography, 54(1), 148-150. doi:10.1107/S0907444997008366

Scopus Eid


  • 2-s2.0-0031938564

Start Page


  • 148

End Page


  • 150

Volume


  • 54

Issue


  • 1

Abstract


  • Human theta-class glutathione S-transferases (GST's) appear to play a critical role in the metabolism of a variety of environmental pollutants but in some cases the products of the reaction are carcinogenic. Crystals of a human theta-class GST, namely hGSTT2-2, have been grown from polyethylene glycol by the hanging-drop vapour-diffusion method. The crystals belong to the trigonal space group P3121 with cell dimensions of a= b = 94.0 and c = 120.5 Å. They contain two monomers in the asymmetric unit and diffract to 3.0 Å resolution.

Publication Date


  • 1998

Citation


  • Mckinstry, W. J., Oakley, A. J., Rossjohn, J., Verger, D., Tan, K. L., Board, P. G., & Parker, M. W. (1998). Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase. Acta Crystallographica Section D: Biological Crystallography, 54(1), 148-150. doi:10.1107/S0907444997008366

Scopus Eid


  • 2-s2.0-0031938564

Start Page


  • 148

End Page


  • 150

Volume


  • 54

Issue


  • 1