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Evolution of functional diversity as observed through structural studies of glutathione transferases

Conference Paper


Abstract


  • Most enzymes bind specifically to one or to a few closely related substrates. However, this is not the case for the enzyme superfamily of glutathione S-transferases (GSTs). The enzyme's ability to recognise a diverse range of substrates is due, in part, to the existence of isoforms. We have determined the crystal structures of GSTs from four classes and from a diverse range of organisms ranging from bacteria to human. These studies are revealing the molecular basis and evolutionary development of how GSTs recognise and react with a structurally diverse array of toxins. © 2001 Elsevier Science Ireland Ltd. All rights reserved.

Publication Date


  • 2001

Citation


  • Parker, M. W., McKinstry, W. J., Oakley, A. J., Polekhina, G., Rossjohn, J., Chelvanayagam, G., . . . Lo Bello, M. (2001). Evolution of functional diversity as observed through structural studies of glutathione transferases. In Chemico-Biological Interactions Vol. 133 (pp. 8-12).

Scopus Eid


  • 2-s2.0-0003139175

Start Page


  • 8

End Page


  • 12

Volume


  • 133

Issue


  • 1-3

Abstract


  • Most enzymes bind specifically to one or to a few closely related substrates. However, this is not the case for the enzyme superfamily of glutathione S-transferases (GSTs). The enzyme's ability to recognise a diverse range of substrates is due, in part, to the existence of isoforms. We have determined the crystal structures of GSTs from four classes and from a diverse range of organisms ranging from bacteria to human. These studies are revealing the molecular basis and evolutionary development of how GSTs recognise and react with a structurally diverse array of toxins. © 2001 Elsevier Science Ireland Ltd. All rights reserved.

Publication Date


  • 2001

Citation


  • Parker, M. W., McKinstry, W. J., Oakley, A. J., Polekhina, G., Rossjohn, J., Chelvanayagam, G., . . . Lo Bello, M. (2001). Evolution of functional diversity as observed through structural studies of glutathione transferases. In Chemico-Biological Interactions Vol. 133 (pp. 8-12).

Scopus Eid


  • 2-s2.0-0003139175

Start Page


  • 8

End Page


  • 12

Volume


  • 133

Issue


  • 1-3