Skip to main content
placeholder image

Structure and function of the bacterial mechanosensitive channel of large conductance

Journal Article


Abstract


  • Mechanosensation in bacteria involves transducing membrane stress into an electrochemical response. In Escherichia coli and other bacteria, this function is carried out by a number of proteins including MscL, the mechanosensitive channel of large conductance. MscL is the best characterized of all mechanosensitive channels. It has been the subject of numerous structural and functional investigations. The explosion in experimental data on MscL recently culminated in the solution of the three-dimensional structure of the MscL homologue from Mycobacterium tuberculosis. In this review, much of these data are united and interpreted in terms of the newly published M. tuberculosis MscL crystal structure.

Publication Date


  • 1999

Citation


  • Oakley, A. J., Martinac, B., & Wilce, M. C. J. (1999). Structure and function of the bacterial mechanosensitive channel of large conductance. Protein Science, 8(10), 1915-1921. doi:10.1110/ps.8.10.1915

Scopus Eid


  • 2-s2.0-0032884395

Start Page


  • 1915

End Page


  • 1921

Volume


  • 8

Issue


  • 10

Abstract


  • Mechanosensation in bacteria involves transducing membrane stress into an electrochemical response. In Escherichia coli and other bacteria, this function is carried out by a number of proteins including MscL, the mechanosensitive channel of large conductance. MscL is the best characterized of all mechanosensitive channels. It has been the subject of numerous structural and functional investigations. The explosion in experimental data on MscL recently culminated in the solution of the three-dimensional structure of the MscL homologue from Mycobacterium tuberculosis. In this review, much of these data are united and interpreted in terms of the newly published M. tuberculosis MscL crystal structure.

Publication Date


  • 1999

Citation


  • Oakley, A. J., Martinac, B., & Wilce, M. C. J. (1999). Structure and function of the bacterial mechanosensitive channel of large conductance. Protein Science, 8(10), 1915-1921. doi:10.1110/ps.8.10.1915

Scopus Eid


  • 2-s2.0-0032884395

Start Page


  • 1915

End Page


  • 1921

Volume


  • 8

Issue


  • 10