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Synthesis of a new series of potent inhibitors of thromboxane A2 biosynthesis

Journal Article


Abstract


  • The pyridino prostanoids 9, 12 and 14 have been synthesized (in racemic form) and have been found to be effective inhibitors of the biosynthesis of thromboxane A2 in human platelets (IC50 1-3 μM). © 1983.

Publication Date


  • 1983

Citation


  • Corey, E. J., Pyne, S. G., & Schafer, A. I. (1983). Synthesis of a new series of potent inhibitors of thromboxane A2 biosynthesis. Tetrahedron Letters, 24(32), 3291-3294. doi:10.1016/S0040-4039(00)86251-6

Scopus Eid


  • 2-s2.0-0020563732

Web Of Science Accession Number


Start Page


  • 3291

End Page


  • 3294

Volume


  • 24

Issue


  • 32

Abstract


  • The pyridino prostanoids 9, 12 and 14 have been synthesized (in racemic form) and have been found to be effective inhibitors of the biosynthesis of thromboxane A2 in human platelets (IC50 1-3 μM). © 1983.

Publication Date


  • 1983

Citation


  • Corey, E. J., Pyne, S. G., & Schafer, A. I. (1983). Synthesis of a new series of potent inhibitors of thromboxane A2 biosynthesis. Tetrahedron Letters, 24(32), 3291-3294. doi:10.1016/S0040-4039(00)86251-6

Scopus Eid


  • 2-s2.0-0020563732

Web Of Science Accession Number


Start Page


  • 3291

End Page


  • 3294

Volume


  • 24

Issue


  • 32