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The search for traces of life: The protective effect of salt on biological macromolecules

Journal Article


Abstract


  • Trapping malate dehydrogenase from the extremely halophilic archaeon Haloarcula marismortui in "dry" salt crystals protects the enzyme against thermal denaturation. Similar protection was not observed for the homologous mesophilic enzyme. In the case of transfer RNA molecules, high salt concentration plays a protective role against thermal degradation allowing activity to be recovered. The results are discussed in the context of exploring the fate of cell-free biological macromolecules in the environment and that of orienting the search for traces of life in planetary exploration. © Springer-Verlag 2002.

Publication Date


  • 2002

Citation


  • Tehei, M., Franzetti, B., Maurel, M. C., Vergne, J., Hountondji, C., & Zaccai, G. (2002). The search for traces of life: The protective effect of salt on biological macromolecules. Extremophiles, 6(5), 427-430. doi:10.1007/s00792-002-0275-6

Scopus Eid


  • 2-s2.0-0036783192

Start Page


  • 427

End Page


  • 430

Volume


  • 6

Issue


  • 5

Abstract


  • Trapping malate dehydrogenase from the extremely halophilic archaeon Haloarcula marismortui in "dry" salt crystals protects the enzyme against thermal denaturation. Similar protection was not observed for the homologous mesophilic enzyme. In the case of transfer RNA molecules, high salt concentration plays a protective role against thermal degradation allowing activity to be recovered. The results are discussed in the context of exploring the fate of cell-free biological macromolecules in the environment and that of orienting the search for traces of life in planetary exploration. © Springer-Verlag 2002.

Publication Date


  • 2002

Citation


  • Tehei, M., Franzetti, B., Maurel, M. C., Vergne, J., Hountondji, C., & Zaccai, G. (2002). The search for traces of life: The protective effect of salt on biological macromolecules. Extremophiles, 6(5), 427-430. doi:10.1007/s00792-002-0275-6

Scopus Eid


  • 2-s2.0-0036783192

Start Page


  • 427

End Page


  • 430

Volume


  • 6

Issue


  • 5