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Calorie restriction in mice: Effects on body composition, daily activity, metabolic rate, mitochondrial reactive oxygen species production, and membrane fatty acid composition

Journal Article


Abstract


  • Different levels of calorie restriction (CR) (125, 85, 50, or 40 kcal/wk for 1, 3, and 6 months) were examined in mice by using the paradigm of Weindruch and colleagues. Lean and total body mass increased on 125 and 85 kcal/wk, but there was negligible growth on low-energy intake. There was no CR-induced reduction in either daily activity or mass-specific metabolic rate. There was no CR-effect on in vitro reactive oxygen species production by liver or muscle mitochondria at 3 months, but after 6 months the effect was significantly reduced in liver mitochondria from 40 kcal/wk mice compared to 125 kcal/wk mice. Changes in the fatty acid composition of phospholipids from liver, kidneys, heart, brain, and skeletal muscle were observed following 1 month of CR. Copyright 2006 by The Gerontological Society of America.

UOW Authors


  •   Else, Paul
  •   Hulbert, Anthony (external author)

Publication Date


  • 2006

Citation


  • Faulks, S. C., Turner, N., Else, P. L., & Hulbert, A. J. (2006). Calorie restriction in mice: Effects on body composition, daily activity, metabolic rate, mitochondrial reactive oxygen species production, and membrane fatty acid composition. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 61(8), 781-794. doi:10.1093/gerona/61.8.781

Scopus Eid


  • 2-s2.0-33747472602

Start Page


  • 781

End Page


  • 794

Volume


  • 61

Issue


  • 8

Abstract


  • Different levels of calorie restriction (CR) (125, 85, 50, or 40 kcal/wk for 1, 3, and 6 months) were examined in mice by using the paradigm of Weindruch and colleagues. Lean and total body mass increased on 125 and 85 kcal/wk, but there was negligible growth on low-energy intake. There was no CR-induced reduction in either daily activity or mass-specific metabolic rate. There was no CR-effect on in vitro reactive oxygen species production by liver or muscle mitochondria at 3 months, but after 6 months the effect was significantly reduced in liver mitochondria from 40 kcal/wk mice compared to 125 kcal/wk mice. Changes in the fatty acid composition of phospholipids from liver, kidneys, heart, brain, and skeletal muscle were observed following 1 month of CR. Copyright 2006 by The Gerontological Society of America.

UOW Authors


  •   Else, Paul
  •   Hulbert, Anthony (external author)

Publication Date


  • 2006

Citation


  • Faulks, S. C., Turner, N., Else, P. L., & Hulbert, A. J. (2006). Calorie restriction in mice: Effects on body composition, daily activity, metabolic rate, mitochondrial reactive oxygen species production, and membrane fatty acid composition. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 61(8), 781-794. doi:10.1093/gerona/61.8.781

Scopus Eid


  • 2-s2.0-33747472602

Start Page


  • 781

End Page


  • 794

Volume


  • 61

Issue


  • 8