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Free fatty acids and gestational diabetes mellitus

Journal Article


Abstract


  • Dyslipidaemia is a common finding in the syndrome of gestational diabetes mellitus (GDM). Free fatty acids (FFA) can cause insulin resistance and have a toxic effect on beta cell function. GDM is a syndrome due to insulin resistance and the purpose of this study was to examine FFA levels in pregnancy. For this purpose samples were taken from 44 consecutive women with GDM and 36 consecutive controls. The women with GDM had similar levels of insulin, triglycerides and total cholesterol to the controls but a significant elevation in FFA; 0.70 (0.33) mmol/L versus 0.29 (0.12) mmol/L (p < 0.0001). A raised level of FFA may be responsible for the insulin resistance of GDM and may assist in the diagnosis.

UOW Authors


  •   Calvert, Dennis D. (external author)
  •   Meyer, Barbara
  •   Moses, Robert (external author)

Publication Date


  • 1996

Citation


  • Meyer, B., Calvert, D., & Moses, R. (1996). Free fatty acids and gestational diabetes mellitus. Australian and New Zealand Journal of Obstetrics and Gynaecology, 36(3), 255-257. doi:10.1111/j.1479-828X.1996.tb02705.x

Scopus Eid


  • 2-s2.0-0029760260

Start Page


  • 255

End Page


  • 257

Volume


  • 36

Issue


  • 3

Abstract


  • Dyslipidaemia is a common finding in the syndrome of gestational diabetes mellitus (GDM). Free fatty acids (FFA) can cause insulin resistance and have a toxic effect on beta cell function. GDM is a syndrome due to insulin resistance and the purpose of this study was to examine FFA levels in pregnancy. For this purpose samples were taken from 44 consecutive women with GDM and 36 consecutive controls. The women with GDM had similar levels of insulin, triglycerides and total cholesterol to the controls but a significant elevation in FFA; 0.70 (0.33) mmol/L versus 0.29 (0.12) mmol/L (p < 0.0001). A raised level of FFA may be responsible for the insulin resistance of GDM and may assist in the diagnosis.

UOW Authors


  •   Calvert, Dennis D. (external author)
  •   Meyer, Barbara
  •   Moses, Robert (external author)

Publication Date


  • 1996

Citation


  • Meyer, B., Calvert, D., & Moses, R. (1996). Free fatty acids and gestational diabetes mellitus. Australian and New Zealand Journal of Obstetrics and Gynaecology, 36(3), 255-257. doi:10.1111/j.1479-828X.1996.tb02705.x

Scopus Eid


  • 2-s2.0-0029760260

Start Page


  • 255

End Page


  • 257

Volume


  • 36

Issue


  • 3