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Asymmetric synthesis of (1R,2S,3R)-2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole

Journal Article


Abstract


  • A method for preparing the biologically active compound (1R,2S,3R)-2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole 1 using a palladium (0) catalysed coupling of 1-ethoxymethyl-4-iodomidazole 2 to the functionalised vinylstannane 3 and the Sharpless catalytic asymmetric dihydroxylation is reported.

Publication Date


  • 1995

Citation


  • Cliff, M. D., & Pyne, S. G. (1995). Asymmetric synthesis of (1R,2S,3R)-2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole. Tetrahedron Letters, 36(33), 5969-5972. doi:10.1016/0040-4039(95)01155-b

Scopus Eid


  • 2-s2.0-0029088636

Web Of Science Accession Number


Start Page


  • 5969

End Page


  • 5972

Volume


  • 36

Issue


  • 33

Abstract


  • A method for preparing the biologically active compound (1R,2S,3R)-2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole 1 using a palladium (0) catalysed coupling of 1-ethoxymethyl-4-iodomidazole 2 to the functionalised vinylstannane 3 and the Sharpless catalytic asymmetric dihydroxylation is reported.

Publication Date


  • 1995

Citation


  • Cliff, M. D., & Pyne, S. G. (1995). Asymmetric synthesis of (1R,2S,3R)-2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole. Tetrahedron Letters, 36(33), 5969-5972. doi:10.1016/0040-4039(95)01155-b

Scopus Eid


  • 2-s2.0-0029088636

Web Of Science Accession Number


Start Page


  • 5969

End Page


  • 5972

Volume


  • 36

Issue


  • 33