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Synthesis of sterically congested 1,5-disubstituted-1,2,3-Triazoles using chloromagnesium acetylides and hindered 1-naphthyl azides

Journal Article


Abstract


  • Sterically congested 1-(2-methoxy-1-naphthyl)-5-substituted-1,2,3-triazoles can be prepared from sterically hindered 2-methoxy-1-azidonaphthalene and chloromagnesium acetylides, including 2-substituted phenylacetylides. Catalytic methods using Cp∗RuCl(PPh3)2 or Cp2Ni/Xanphos were not successful.

Publication Date


  • 2021

Citation


  • Mahadari, M. K., Tague, A. J., Keller, P. A., & Pyne, S. G. (2021). Synthesis of sterically congested 1,5-disubstituted-1,2,3-Triazoles using chloromagnesium acetylides and hindered 1-naphthyl azides. Tetrahedron, 81. doi:10.1016/j.tet.2020.131916

Scopus Eid


  • 2-s2.0-85099303079

Volume


  • 81

Abstract


  • Sterically congested 1-(2-methoxy-1-naphthyl)-5-substituted-1,2,3-triazoles can be prepared from sterically hindered 2-methoxy-1-azidonaphthalene and chloromagnesium acetylides, including 2-substituted phenylacetylides. Catalytic methods using Cp∗RuCl(PPh3)2 or Cp2Ni/Xanphos were not successful.

Publication Date


  • 2021

Citation


  • Mahadari, M. K., Tague, A. J., Keller, P. A., & Pyne, S. G. (2021). Synthesis of sterically congested 1,5-disubstituted-1,2,3-Triazoles using chloromagnesium acetylides and hindered 1-naphthyl azides. Tetrahedron, 81. doi:10.1016/j.tet.2020.131916

Scopus Eid


  • 2-s2.0-85099303079

Volume


  • 81