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Microprobe X-ray absorption spectroscopic determination of the oxidation state of intracellular chromium following exposure of V79 Chinese hamster lung cells to genotoxic chromium complexes.

Journal Article


Abstract


  • The oxidation state of intracellular chromium has been determined directly in mammalian lung cells exposed to mutagenic and carcinogenic chromium compounds. Microprobe X-ray absorption spectroscopy (XAS) experiments on single V79 Chinese hamster lung cells showed that Cr(VI) and Cr(V) complexes were reduced completely (>90%) to Cr(III) within 4 h of exposure of the cells. This result provides direct evidence for the hypothesis that these genotoxic oxidants react rapidly with intracellular reductants.

Publication Date


  • 1997

Citation


  • Dillon, C. T., Lay, P. A., Cholewa, M., Legge, G. J., Bonin, A. M., Collins, T. J., . . . Shea-McCarthy, G. (1997). Microprobe X-ray absorption spectroscopic determination of the oxidation state of intracellular chromium following exposure of V79 Chinese hamster lung cells to genotoxic chromium complexes.. Chemical research in toxicology, 10(5), 533-535. doi:10.1021/tx970010m

Web Of Science Accession Number


Start Page


  • 533

End Page


  • 535

Volume


  • 10

Issue


  • 5

Abstract


  • The oxidation state of intracellular chromium has been determined directly in mammalian lung cells exposed to mutagenic and carcinogenic chromium compounds. Microprobe X-ray absorption spectroscopy (XAS) experiments on single V79 Chinese hamster lung cells showed that Cr(VI) and Cr(V) complexes were reduced completely (>90%) to Cr(III) within 4 h of exposure of the cells. This result provides direct evidence for the hypothesis that these genotoxic oxidants react rapidly with intracellular reductants.

Publication Date


  • 1997

Citation


  • Dillon, C. T., Lay, P. A., Cholewa, M., Legge, G. J., Bonin, A. M., Collins, T. J., . . . Shea-McCarthy, G. (1997). Microprobe X-ray absorption spectroscopic determination of the oxidation state of intracellular chromium following exposure of V79 Chinese hamster lung cells to genotoxic chromium complexes.. Chemical research in toxicology, 10(5), 533-535. doi:10.1021/tx970010m

Web Of Science Accession Number


Start Page


  • 533

End Page


  • 535

Volume


  • 10

Issue


  • 5