The present investigation was concerned with the implementation of an information system within a health care setting. A large number of staff required training on a new patient management information system (MIS). The aim of this study was to assess occupational differences on a number of psychological variables associated with MIS success. Computer anxiety was of primary concern due to its relationship to avoidance of computers. A total of 175 questionnaires were distributed, with 103 questionnaires being completed and returned for analysis (61.1%). It was found that clerical/administrative staff had significantly higher self-efficacy regarding computer use and more experience with computers. The nursing group experienced significantly more, computer anxiety, negative attitudes, and negative expectations than the clerical group. Self-efficacy was found to be the best predictor of computer related anxiety. The results have implications for MIS implementation strategies particularly in the areas of training and resource allocation. © 1995 Taylor & Francis Group, LLC.