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Changes in myocardial eicosanoid production following long-term dietary lipid supplementation in rats

Journal Article


Abstract


  • Recent studies demonstrate a strong link between the type of fat consumed and arrhythmogenesis and implicate altered production of eicosanoids as a potential mechanism. Thus, in a preliminary study designed to evaluate this hypothesis, five dietary lipid supplements - sunflower seed oil (SSO), chemically refined palm oil (PO I), physically refined palm oil (PO II), sheep fat (SF), and a 1:1 blend of SF and fish oil (SF-FO) - were compared for their effects on membrane-lipid composition and eicosanoid synthesis after a 12-mo prefeeding period. Polyunsaturated fatty acids (PUFAs) of the myocardium showed significant alterations in response to dietary lipid treatment. Nevertheless, prostacyclin production was unaffected whereas both SF-FO and POI diets caused a significant inhibition of myocardial thromboxane A2 (TXA2). It is speculated that n-3 (ω-3) PUFAs may act as specific inhibitors of TXA2 synthetase whereas the PO I effect is unlikely to be mediated via fatty acids. These preliminary data are worthy of further investigation.

UOW Authors


  •   McLennan, Peter (external author)

Publication Date


  • 1991

Citation


  • Abeywardena, M. Y., McLennan, P. L., & Charnock, J. S. (1991). Changes in myocardial eicosanoid production following long-term dietary lipid supplementation in rats. American Journal of Clinical Nutrition, 53(4 SUPPL.). doi:10.1093/ajcn/53.4.1039S

Scopus Eid


  • 2-s2.0-0025904763

Volume


  • 53

Issue


  • 4 SUPPL.

Abstract


  • Recent studies demonstrate a strong link between the type of fat consumed and arrhythmogenesis and implicate altered production of eicosanoids as a potential mechanism. Thus, in a preliminary study designed to evaluate this hypothesis, five dietary lipid supplements - sunflower seed oil (SSO), chemically refined palm oil (PO I), physically refined palm oil (PO II), sheep fat (SF), and a 1:1 blend of SF and fish oil (SF-FO) - were compared for their effects on membrane-lipid composition and eicosanoid synthesis after a 12-mo prefeeding period. Polyunsaturated fatty acids (PUFAs) of the myocardium showed significant alterations in response to dietary lipid treatment. Nevertheless, prostacyclin production was unaffected whereas both SF-FO and POI diets caused a significant inhibition of myocardial thromboxane A2 (TXA2). It is speculated that n-3 (ω-3) PUFAs may act as specific inhibitors of TXA2 synthetase whereas the PO I effect is unlikely to be mediated via fatty acids. These preliminary data are worthy of further investigation.

UOW Authors


  •   McLennan, Peter (external author)

Publication Date


  • 1991

Citation


  • Abeywardena, M. Y., McLennan, P. L., & Charnock, J. S. (1991). Changes in myocardial eicosanoid production following long-term dietary lipid supplementation in rats. American Journal of Clinical Nutrition, 53(4 SUPPL.). doi:10.1093/ajcn/53.4.1039S

Scopus Eid


  • 2-s2.0-0025904763

Volume


  • 53

Issue


  • 4 SUPPL.