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Comparative efficacy of n-3 and n-6 polyunsaturated fatty acids in modulating ventricular fibrillation threshold in marmoset monkeys

Journal Article


Abstract


  • Programmed electrical stimulation in anesthetized marmoset monkeys was used to examine relative antiarrhythmic efficacies of dietary n-3 and n-6 polyunsaturated fatty acids (PUFAs) from fish and plant oils. Diets contained 31% of energy (en%) as fat, comprising 15 en% saturated fat and 7 en% PUFAs, obtained by blending sheep fat with sunflower seed (SF/SSO) or fish oil (SF/FO) and a base diet. After 16-wk feeding, ventricular fibrillation (VF) was inducible in 6 of 10 animals on each diet under control conditions. The VF threshold (VFT) was significantly elevated in the SF/FO group (33.3 ± 3.1 mA; n = 6) compared with the SF/SSO group (14.3 ± 4.9 mA; n = 6). VFT, reduced during acute myocardial ischemia with 10 of 10 animals inducible per diet, remained significantly higher with SF/FO feeding. The SF/FO diet contained 3.8 en% as n-3 PUFAs, which was incorporated as 31% of myocardial membrane fatty acids. Dietary n-3 PUFA reduced vulnerability of normal or ischemic myocardium to arrhythmias in a nonhuman primate.

UOW Authors


  •   McLennan, Peter (external author)

Publication Date


  • 1993

Citation


  • McLennan, P. L., Bridle, T. M., Abeywardena, M. Y., & Charnock, J. S. (1993). Comparative efficacy of n-3 and n-6 polyunsaturated fatty acids in modulating ventricular fibrillation threshold in marmoset monkeys. American Journal of Clinical Nutrition, 58(5), 666-669. doi:10.1093/ajcn/58.5.666

Scopus Eid


  • 2-s2.0-0027486661

Start Page


  • 666

End Page


  • 669

Volume


  • 58

Issue


  • 5

Abstract


  • Programmed electrical stimulation in anesthetized marmoset monkeys was used to examine relative antiarrhythmic efficacies of dietary n-3 and n-6 polyunsaturated fatty acids (PUFAs) from fish and plant oils. Diets contained 31% of energy (en%) as fat, comprising 15 en% saturated fat and 7 en% PUFAs, obtained by blending sheep fat with sunflower seed (SF/SSO) or fish oil (SF/FO) and a base diet. After 16-wk feeding, ventricular fibrillation (VF) was inducible in 6 of 10 animals on each diet under control conditions. The VF threshold (VFT) was significantly elevated in the SF/FO group (33.3 ± 3.1 mA; n = 6) compared with the SF/SSO group (14.3 ± 4.9 mA; n = 6). VFT, reduced during acute myocardial ischemia with 10 of 10 animals inducible per diet, remained significantly higher with SF/FO feeding. The SF/FO diet contained 3.8 en% as n-3 PUFAs, which was incorporated as 31% of myocardial membrane fatty acids. Dietary n-3 PUFA reduced vulnerability of normal or ischemic myocardium to arrhythmias in a nonhuman primate.

UOW Authors


  •   McLennan, Peter (external author)

Publication Date


  • 1993

Citation


  • McLennan, P. L., Bridle, T. M., Abeywardena, M. Y., & Charnock, J. S. (1993). Comparative efficacy of n-3 and n-6 polyunsaturated fatty acids in modulating ventricular fibrillation threshold in marmoset monkeys. American Journal of Clinical Nutrition, 58(5), 666-669. doi:10.1093/ajcn/58.5.666

Scopus Eid


  • 2-s2.0-0027486661

Start Page


  • 666

End Page


  • 669

Volume


  • 58

Issue


  • 5