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Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-: A] pyrimidines as potential anti-chikungunya agents

Journal Article


Abstract


  • Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the Z configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.

UOW Authors


Publication Date


  • 2020

Citation


  • Fares, M., McCosker, P. M., Alsherbiny, M. A., Willis, A. C., Clark, T., Neyts, J., . . . Keller, P. A. (2020). Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-: A] pyrimidines as potential anti-chikungunya agents. RSC Advances, 10(9), 5191-5195. doi:10.1039/d0ra00257g

Scopus Eid


  • 2-s2.0-85079352028

Start Page


  • 5191

End Page


  • 5195

Volume


  • 10

Issue


  • 9

Abstract


  • Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the Z configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.

UOW Authors


Publication Date


  • 2020

Citation


  • Fares, M., McCosker, P. M., Alsherbiny, M. A., Willis, A. C., Clark, T., Neyts, J., . . . Keller, P. A. (2020). Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-: A] pyrimidines as potential anti-chikungunya agents. RSC Advances, 10(9), 5191-5195. doi:10.1039/d0ra00257g

Scopus Eid


  • 2-s2.0-85079352028

Start Page


  • 5191

End Page


  • 5195

Volume


  • 10

Issue


  • 9