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Ultrasmall Biocompatible Bi2Se3 Nanodots for Multimodal Imaging-Guided Synergistic Radiophotothermal Therapy against Cancer

Journal Article


Abstract


  • Sub-3 nm ultrasmall Bi2Se3 nanodots stabilized with bovine serum albumin were successfully synthesized through a reaction of hydroxyethylthioselenide with bismuth chloride in aqueous solution under ambient conditions. These nanodots exhibit a high photothermal conversion efficiency (�� = 50.7%) due to their strong broad absorbance in the near-infrared (NIR) window and serve as a nanotheranostic agent for photoacoustic imaging and photothermal cancer therapy. In addition, they also display radioenhancement with a ratio of 6% due to their sensitivity to X-rays, which makes them a potential sensitizer for radiotherapy. These nanodots were also labled with radioactive 99mTc for quantification of their biodistribution by single-photon-emission computed tomography (SPECT)/computed tomography (CT) imaging. Our work demonstrates the potential of ultrasmall Bi2Se3 nanodots in multimodal imaging-guided synergetic radiophotothermal therapy of cancer.

UOW Authors


  •   Li, Zhen (external author)

Publication Date


  • 2016

Citation


  • Mao, F., Wen, L., Sun, C., Zhang, S., Wang, G., Zeng, J., . . . Li, Z. (2016). Ultrasmall Biocompatible Bi2Se3 Nanodots for Multimodal Imaging-Guided Synergistic Radiophotothermal Therapy against Cancer. ACS Nano, 10(12), 11145-11155. doi:10.1021/acsnano.6b06067

Scopus Eid


  • 2-s2.0-85008511947

Start Page


  • 11145

End Page


  • 11155

Volume


  • 10

Issue


  • 12

Place Of Publication


Abstract


  • Sub-3 nm ultrasmall Bi2Se3 nanodots stabilized with bovine serum albumin were successfully synthesized through a reaction of hydroxyethylthioselenide with bismuth chloride in aqueous solution under ambient conditions. These nanodots exhibit a high photothermal conversion efficiency (�� = 50.7%) due to their strong broad absorbance in the near-infrared (NIR) window and serve as a nanotheranostic agent for photoacoustic imaging and photothermal cancer therapy. In addition, they also display radioenhancement with a ratio of 6% due to their sensitivity to X-rays, which makes them a potential sensitizer for radiotherapy. These nanodots were also labled with radioactive 99mTc for quantification of their biodistribution by single-photon-emission computed tomography (SPECT)/computed tomography (CT) imaging. Our work demonstrates the potential of ultrasmall Bi2Se3 nanodots in multimodal imaging-guided synergetic radiophotothermal therapy of cancer.

UOW Authors


  •   Li, Zhen (external author)

Publication Date


  • 2016

Citation


  • Mao, F., Wen, L., Sun, C., Zhang, S., Wang, G., Zeng, J., . . . Li, Z. (2016). Ultrasmall Biocompatible Bi2Se3 Nanodots for Multimodal Imaging-Guided Synergistic Radiophotothermal Therapy against Cancer. ACS Nano, 10(12), 11145-11155. doi:10.1021/acsnano.6b06067

Scopus Eid


  • 2-s2.0-85008511947

Start Page


  • 11145

End Page


  • 11155

Volume


  • 10

Issue


  • 12

Place Of Publication