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(1R,3R)-1,3-Dimethyl-8-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride ��� an Enantiomerically Pure Building Block for the Synthesis of Naphthylisoquinoline Alkaloids

Journal Article


Abstract


  • The title compound was prepared by hydrogenolytic deprotection of the corresponding N-benzyl derivative, which had previously been synthesized by a Picted-Spengler condensation of the corresponding arylethylamine. It crystallizes from dichloromethane/methanol in the orthorhombic system, space group P212121; a = 1305.7(2), b = 1400.3(3), c =727.4(1) pm. Hydrogen bonds between Cl and OH and NH2 groups cause a three-dimensional arrangement. �� 1995 Verlag der Zeitschrift f��r Naturforschung. All rights reserved.

Publication Date


  • 1995

Citation


  • Peters, K., Peters, E. M., Bringmann, G., Keller, P. A., & Sch��ffer, M. (1995). (1R,3R)-1,3-Dimethyl-8-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride ��� an Enantiomerically Pure Building Block for the Synthesis of Naphthylisoquinoline Alkaloids. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 50(7), 1137-1140. doi:10.1515/znb-1995-0729

Scopus Eid


  • 2-s2.0-21844519754

Start Page


  • 1137

End Page


  • 1140

Volume


  • 50

Issue


  • 7

Place Of Publication


Abstract


  • The title compound was prepared by hydrogenolytic deprotection of the corresponding N-benzyl derivative, which had previously been synthesized by a Picted-Spengler condensation of the corresponding arylethylamine. It crystallizes from dichloromethane/methanol in the orthorhombic system, space group P212121; a = 1305.7(2), b = 1400.3(3), c =727.4(1) pm. Hydrogen bonds between Cl and OH and NH2 groups cause a three-dimensional arrangement. �� 1995 Verlag der Zeitschrift f��r Naturforschung. All rights reserved.

Publication Date


  • 1995

Citation


  • Peters, K., Peters, E. M., Bringmann, G., Keller, P. A., & Sch��ffer, M. (1995). (1R,3R)-1,3-Dimethyl-8-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride ��� an Enantiomerically Pure Building Block for the Synthesis of Naphthylisoquinoline Alkaloids. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 50(7), 1137-1140. doi:10.1515/znb-1995-0729

Scopus Eid


  • 2-s2.0-21844519754

Start Page


  • 1137

End Page


  • 1140

Volume


  • 50

Issue


  • 7

Place Of Publication