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First total synthesis of korupensamines A and B

Journal Article


Abstract


  • The first total synthesis of korupensamines A (1a) and B (1b), highly polar naphthylisoquinoline alkaloids and, simultaneously, 'monomeric building blocks' of the michellamines, is described. Key step is the Pd��� catalyzed intermolecular biaryl coupling of the two appropriately protected naphthalene and isoquinoline moieties (10) and (11), with the coupling positions activated by bromine and trialkylstannane substituents respectively. �� 1994.

Publication Date


  • 1994

Citation


  • Bringmann, G., G��tz, R., Keller, P. A., Walter, R., Henschel, P., Sch��ffer, M., . . . Boyd, M. R. (1994). First total synthesis of korupensamines A and B. Heterocycles, 39(2), 503-508. doi:10.3987/COM-94-S(B)79

Scopus Eid


  • 2-s2.0-0001537132

Start Page


  • 503

End Page


  • 508

Volume


  • 39

Issue


  • 2

Place Of Publication


Abstract


  • The first total synthesis of korupensamines A (1a) and B (1b), highly polar naphthylisoquinoline alkaloids and, simultaneously, 'monomeric building blocks' of the michellamines, is described. Key step is the Pd��� catalyzed intermolecular biaryl coupling of the two appropriately protected naphthalene and isoquinoline moieties (10) and (11), with the coupling positions activated by bromine and trialkylstannane substituents respectively. �� 1994.

Publication Date


  • 1994

Citation


  • Bringmann, G., G��tz, R., Keller, P. A., Walter, R., Henschel, P., Sch��ffer, M., . . . Boyd, M. R. (1994). First total synthesis of korupensamines A and B. Heterocycles, 39(2), 503-508. doi:10.3987/COM-94-S(B)79

Scopus Eid


  • 2-s2.0-0001537132

Start Page


  • 503

End Page


  • 508

Volume


  • 39

Issue


  • 2

Place Of Publication