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The gut microbiota promotes the pathogenesis of schizophrenia via multiple pathways

Journal Article


Abstract


  • Schizophrenia is a severe mental disorder with unknown etiology. Many mechanisms, including dysregulation of neurotransmitters, immune disturbance, and abnormal neurodevelopment, are proposed for the pathogenesis of schizophrenia. The significance of communication between intestinal flora and the central nervous system through the gut-brain axis is increasingly being recognized. The intestinal microbiota plays an important role in regulating neurotransmission, immune homeostasis, and brain development. We hypothesize that an imbalance in intestinal flora causes immune activation and dysfunction in the gut-brain axis, contributing to schizophrenia. In this review, we examine recent studies that explore the intestinal flora and immune-mediated neurodevelopment of schizophrenia. We conclude that an imbalance in intestinal flora may reduce protectants and increase neurotoxin and inflammatory mediators, causing neuronal and synaptic damage, which induces schizophrenia.

Publication Date


  • 2019

Citation


  • Yuan, X., Kang, Y., Zhuo, C., Huang, X. F., & Song, X. (2019). The gut microbiota promotes the pathogenesis of schizophrenia via multiple pathways. Biochemical and Biophysical Research Communications, 512(2), 373-380. doi:10.1016/j.bbrc.2019.02.152

Scopus Eid


  • 2-s2.0-85064449961

Start Page


  • 373

End Page


  • 380

Volume


  • 512

Issue


  • 2

Abstract


  • Schizophrenia is a severe mental disorder with unknown etiology. Many mechanisms, including dysregulation of neurotransmitters, immune disturbance, and abnormal neurodevelopment, are proposed for the pathogenesis of schizophrenia. The significance of communication between intestinal flora and the central nervous system through the gut-brain axis is increasingly being recognized. The intestinal microbiota plays an important role in regulating neurotransmission, immune homeostasis, and brain development. We hypothesize that an imbalance in intestinal flora causes immune activation and dysfunction in the gut-brain axis, contributing to schizophrenia. In this review, we examine recent studies that explore the intestinal flora and immune-mediated neurodevelopment of schizophrenia. We conclude that an imbalance in intestinal flora may reduce protectants and increase neurotoxin and inflammatory mediators, causing neuronal and synaptic damage, which induces schizophrenia.

Publication Date


  • 2019

Citation


  • Yuan, X., Kang, Y., Zhuo, C., Huang, X. F., & Song, X. (2019). The gut microbiota promotes the pathogenesis of schizophrenia via multiple pathways. Biochemical and Biophysical Research Communications, 512(2), 373-380. doi:10.1016/j.bbrc.2019.02.152

Scopus Eid


  • 2-s2.0-85064449961

Start Page


  • 373

End Page


  • 380

Volume


  • 512

Issue


  • 2