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Resolving the Gordian Knot: Srs2 Strips Intermediates Formed during Homologous Recombination

Journal Article


Abstract


  • Cells use a suite of specialized enzymes to repair chromosomal double-strand breaks (DSBs). Two recent studies describe how single-molecule fluorescence imaging techniques are used in the direct visualization of some of the key molecular steps involved. De Tullio et al. and Kaniecki et al. watch individual Srs2 helicase molecules disrupt repair intermediates formed by RPA, Rad51, and Rad52 on DNA during homologous recombination.

Publication Date


  • 2018

Citation


  • Ghodke, H., Lewis, J. S., & van Oijen, A. M. (2018). Resolving the Gordian Knot: Srs2 Strips Intermediates Formed during Homologous Recombination. Trends in Biochemical Sciences, 43(3), 149-151. doi:10.1016/j.tibs.2017.12.004

Scopus Eid


  • 2-s2.0-85042404707

Start Page


  • 149

End Page


  • 151

Volume


  • 43

Issue


  • 3

Abstract


  • Cells use a suite of specialized enzymes to repair chromosomal double-strand breaks (DSBs). Two recent studies describe how single-molecule fluorescence imaging techniques are used in the direct visualization of some of the key molecular steps involved. De Tullio et al. and Kaniecki et al. watch individual Srs2 helicase molecules disrupt repair intermediates formed by RPA, Rad51, and Rad52 on DNA during homologous recombination.

Publication Date


  • 2018

Citation


  • Ghodke, H., Lewis, J. S., & van Oijen, A. M. (2018). Resolving the Gordian Knot: Srs2 Strips Intermediates Formed during Homologous Recombination. Trends in Biochemical Sciences, 43(3), 149-151. doi:10.1016/j.tibs.2017.12.004

Scopus Eid


  • 2-s2.0-85042404707

Start Page


  • 149

End Page


  • 151

Volume


  • 43

Issue


  • 3