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Stimuli-Responsive Cycloaurated “OFF-ON” Switchable Anion Transporters

Journal Article


Abstract


  • Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes of anion transporters that are “switched on” in situ in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in higher concentrations in tumors than in healthy tissue and hence this approach offers a strategy to target these systems to tumors.

Publication Date


  • 2020

Citation


  • Fares, M., Wu, X., Ramesh, D., Lewis, W., Keller, P. A., Howe, E. N. W., . . . Gale, P. A. (2020). Stimuli-Responsive Cycloaurated “OFF-ON” Switchable Anion Transporters. Angewandte Chemie - International Edition, 59(40), 17614-17621. doi:10.1002/anie.202006392

Scopus Eid


  • 2-s2.0-85089300166

Start Page


  • 17614

End Page


  • 17621

Volume


  • 59

Issue


  • 40

Abstract


  • Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes of anion transporters that are “switched on” in situ in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in higher concentrations in tumors than in healthy tissue and hence this approach offers a strategy to target these systems to tumors.

Publication Date


  • 2020

Citation


  • Fares, M., Wu, X., Ramesh, D., Lewis, W., Keller, P. A., Howe, E. N. W., . . . Gale, P. A. (2020). Stimuli-Responsive Cycloaurated “OFF-ON” Switchable Anion Transporters. Angewandte Chemie - International Edition, 59(40), 17614-17621. doi:10.1002/anie.202006392

Scopus Eid


  • 2-s2.0-85089300166

Start Page


  • 17614

End Page


  • 17621

Volume


  • 59

Issue


  • 40