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A new secoiridoid glycoside and other constituents from the roots and flowers of Fagraea fragrans Roxb. (Gentianaceae)

Journal Article


Abstract


  • A new secoiridoid glycoside, 3’-O-p-trans-coumaroylsweroside (1), together with twenty-nine compounds (2–30), were isolated from the roots and flowers of Fagraea fragrans Roxb. (Gentianaceae). Their structures were identified by analysis of mass spectrometric and NMR spectroscopic data. Compounds 2, 4, 6, 11 and 13–15 showed weak to moderate cytotoxicity against cholangiocarcinoma cancer cells lines (KKU-213, KKU-055 and KKU-214). We report the first phytochemical investigation of the roots and flowers of F. fragrans, as only the essential oil of the latter has been investigated.

Publication Date


  • 2020

Citation


  • Sangsopha, W., Lekphrom, R., Schevenels, F. T., Byatt, B., Pyne, S. G., Sridadom, N., & Sawanyawisuth, K. (2020). A new secoiridoid glycoside and other constituents from the roots and flowers of Fagraea fragrans Roxb. (Gentianaceae). Natural Product Research. doi:10.1080/14786419.2020.1749611

Scopus Eid


  • 2-s2.0-85084838308

Web Of Science Accession Number


Abstract


  • A new secoiridoid glycoside, 3’-O-p-trans-coumaroylsweroside (1), together with twenty-nine compounds (2–30), were isolated from the roots and flowers of Fagraea fragrans Roxb. (Gentianaceae). Their structures were identified by analysis of mass spectrometric and NMR spectroscopic data. Compounds 2, 4, 6, 11 and 13–15 showed weak to moderate cytotoxicity against cholangiocarcinoma cancer cells lines (KKU-213, KKU-055 and KKU-214). We report the first phytochemical investigation of the roots and flowers of F. fragrans, as only the essential oil of the latter has been investigated.

Publication Date


  • 2020

Citation


  • Sangsopha, W., Lekphrom, R., Schevenels, F. T., Byatt, B., Pyne, S. G., Sridadom, N., & Sawanyawisuth, K. (2020). A new secoiridoid glycoside and other constituents from the roots and flowers of Fagraea fragrans Roxb. (Gentianaceae). Natural Product Research. doi:10.1080/14786419.2020.1749611

Scopus Eid


  • 2-s2.0-85084838308

Web Of Science Accession Number