Skip to main content
placeholder image

Phloroglucinol Benzophenones and Xanthones from the Leaves of Garcinia cowa and Their Nitric Oxide Production and ¿-Glucosidase Inhibitory Activities

Journal Article


Abstract


  • Five new compounds - two phloroglucinol benzophenones, garciniacowones F (1) and G (2), and three xanthones, garciniacowones H (3), I (4), and J (5) - together with seven known xanthones (6-12) were isolated from the fresh leaves of Garcinia cowa. Their structures were elucidated by detailed analysis of NMR and MS data. Compounds 1 and 2 are phloroglucinol benzophenones containing a polyprenylated bicyclo[3.3.1]nonane ring system, while compounds 3-5 are rare xanthones having farnesyl (3 and 5) and geranylgeranyl (5) units at C-8. Compounds 1, 3, 4, 7, 8, and 10 exhibited inhibitory effects on NO production in LPS-induced RAW264.7 macrophage cells with IC50 values ranging from 5.4 to 18.6 μM. Compounds 4 and 8 had α-glucosidase inhibitory activities with IC50 values of 15.4 and 11.4 μM, respectively, which were more potent than that of the acarbose control.

Publication Date


  • 2020

Citation


  • Raksat, A., Phukhatmuen, P., Yang, J., Maneerat, W., Charoensup, R., Andersen, R. J., . . . Laphookhieo, S. (2020). Phloroglucinol Benzophenones and Xanthones from the Leaves of Garcinia cowa and Their Nitric Oxide Production and ¿-Glucosidase Inhibitory Activities. Journal of Natural Products, 83(1), 164-168. doi:10.1021/acs.jnatprod.9b00849

Scopus Eid


  • 2-s2.0-85077153977

Start Page


  • 164

End Page


  • 168

Volume


  • 83

Issue


  • 1

Abstract


  • Five new compounds - two phloroglucinol benzophenones, garciniacowones F (1) and G (2), and three xanthones, garciniacowones H (3), I (4), and J (5) - together with seven known xanthones (6-12) were isolated from the fresh leaves of Garcinia cowa. Their structures were elucidated by detailed analysis of NMR and MS data. Compounds 1 and 2 are phloroglucinol benzophenones containing a polyprenylated bicyclo[3.3.1]nonane ring system, while compounds 3-5 are rare xanthones having farnesyl (3 and 5) and geranylgeranyl (5) units at C-8. Compounds 1, 3, 4, 7, 8, and 10 exhibited inhibitory effects on NO production in LPS-induced RAW264.7 macrophage cells with IC50 values ranging from 5.4 to 18.6 μM. Compounds 4 and 8 had α-glucosidase inhibitory activities with IC50 values of 15.4 and 11.4 μM, respectively, which were more potent than that of the acarbose control.

Publication Date


  • 2020

Citation


  • Raksat, A., Phukhatmuen, P., Yang, J., Maneerat, W., Charoensup, R., Andersen, R. J., . . . Laphookhieo, S. (2020). Phloroglucinol Benzophenones and Xanthones from the Leaves of Garcinia cowa and Their Nitric Oxide Production and ¿-Glucosidase Inhibitory Activities. Journal of Natural Products, 83(1), 164-168. doi:10.1021/acs.jnatprod.9b00849

Scopus Eid


  • 2-s2.0-85077153977

Start Page


  • 164

End Page


  • 168

Volume


  • 83

Issue


  • 1