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Unique polyacetylenic ester-neolignan derivatives from Mitrephora tomentosa and their antimalarial activities

Journal Article


Abstract


  • The phytochemical investigation of the methanol extracts of the leaves and twigs of Mitrephora tomentosa Hook. f. & Thomson resulted in the isolation and identification of undescribed polyacetylenic ester-neolignan derivatives, along with six known compounds. These six undescribed natural products were named as mitrephentosins A-F. The structures of these compounds were determined by spectroscopic techniques including UV, IR, NMR, and mass spectrometric analyses. The absolute configurations of mitrephentosins A-F were determined based on specific rotations values and ECD spectral data by comparisons made with the known parent neoligan compound mitredrusin. Mitrephentosins C, E, and F showed moderate antimalarial activities (IC50 values of 13.3–24.6 μM) against the Plasmodium falciparum strains TM4/8.2 and K1CB1 and were not toxic to Vero cells, while the other isolated compounds were not active against these P. falciparum strains.

Publication Date


  • 2021

Citation


  • Wongsomboon, P., Rattanajak, R., Kamchonwongpaisan, S., Pyne, S. G., & Limtharakul, T. (2021). Unique polyacetylenic ester-neolignan derivatives from Mitrephora tomentosa and their antimalarial activities. Phytochemistry, 183. doi:10.1016/j.phytochem.2020.112615

Scopus Eid


  • 2-s2.0-85097899689

Web Of Science Accession Number


Volume


  • 183

Abstract


  • The phytochemical investigation of the methanol extracts of the leaves and twigs of Mitrephora tomentosa Hook. f. & Thomson resulted in the isolation and identification of undescribed polyacetylenic ester-neolignan derivatives, along with six known compounds. These six undescribed natural products were named as mitrephentosins A-F. The structures of these compounds were determined by spectroscopic techniques including UV, IR, NMR, and mass spectrometric analyses. The absolute configurations of mitrephentosins A-F were determined based on specific rotations values and ECD spectral data by comparisons made with the known parent neoligan compound mitredrusin. Mitrephentosins C, E, and F showed moderate antimalarial activities (IC50 values of 13.3–24.6 μM) against the Plasmodium falciparum strains TM4/8.2 and K1CB1 and were not toxic to Vero cells, while the other isolated compounds were not active against these P. falciparum strains.

Publication Date


  • 2021

Citation


  • Wongsomboon, P., Rattanajak, R., Kamchonwongpaisan, S., Pyne, S. G., & Limtharakul, T. (2021). Unique polyacetylenic ester-neolignan derivatives from Mitrephora tomentosa and their antimalarial activities. Phytochemistry, 183. doi:10.1016/j.phytochem.2020.112615

Scopus Eid


  • 2-s2.0-85097899689

Web Of Science Accession Number


Volume


  • 183