The National Facility for Physical Blast Simulation (NFPBS) established at the University of Wollongong, New South Wales, Australia is designed for systematic experimental studies of blast wave propagation and loading regimes, blast damage of elements of civilian and military infrastructure, blast injury protection, and other important blast related areas of research. The simulator is a state-of-the-art design capable of accurately replicating all wave characteristics of an actual free-field explosive blast. This simulator has a Test Section of 1.5 x 2 m and is capable of a range of blast-test configurations including full-reflection wall targets, diffraction model targets, as well as behind-wall and blast-ingress scenarios. This paper aims to specifically demonstrate the capability of the facility for blast-testing of full-reflection wall targets. As an example, recent tests to examine the dynamic response of full-scale reinforced concrete (RC) slabs are given. Through a series of blast-loadings of increasing strength, the response of the slabs ranging from elastic to full collapse was measured with high-speed laser displacement sensors and a high-speed camera to collect dynamic displacement histories and crack patterns. Additionally, correlation of the applied blast-loadings on RC slabs with equivalent TNT charge weights and standoff distances are given. Furthermore, a FE LS-DYNA model was developed and predictions were compared with the experimental results and it was found that LS-DYNA model was able to capture the response of slabs in reasonable manner, but FE model needs further calibration of material model parameters for proper evaluation of the response of one-way RC structures to use for future applications.